Evidence map›Paper›PMID 24304973›Full record

ArticleGenes and immunity2014

Follicular lymphoma-protective HLA class II variants correlate with increased HLA-DQB1 protein expression.

F C M Sillé, L Conde, J Zhang, N K Akers, S Sanchez, J Maltbaek, J E Riby, M T Smith, C F Skibola

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes and immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

F C M SilléDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
L CondeDepartment of Epidemiology, Comprehensive Cancer Center, University of Alabama, Birmingham, AL, USA.
J ZhangDepartment of Epidemiology, Comprehensive Cancer Center, University of Alabama, Birmingham, AL, USA.
N K AkersDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
S SanchezDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
J MaltbaekDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
J E RibyDepartment of Epidemiology, Comprehensive Cancer Center, University of Alabama, Birmingham, AL, USA.
M T SmithDivision of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
C F SkibolaDepartment of Epidemiology, Comprehensive Cancer Center, University of Alabama, Birmingham, AL, USA.
University of California, Berkeley · USUniversity of Alabama at Birmingham · US

Funding

Genetic Susceptibility to Non-Hodgkins LymphomaR01CA104682 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI SKIBOLA, CHRISTINE F. · 2003 to 2012
$2.6M
Resequencing and Functional Studies to Identify Causal Gene Variants of LymphomaR01CA154643 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZHANG, JIANQING · 2011 to 2014
$2.4M
NCI NIH HHS CA104682NCI NIH HHS CA154643NCI NIH HHS R01 CA104682NCI NIH HHS R01 CA154643
6 · The paper itself

Abstract

Multiple follicular lymphoma (FL) susceptibility single-nucleotide polymorphisms in the human leukocyte antigen (HLA) class I and II regions have been identified, including rs6457327, rs3117222, rs2647012, rs10484561, rs9268853 and rs2621416. Here we validated previous expression quantitative trait loci results with real-time reverse transcription quantitative PCR and investigated protein expression in B-lymphoblastoid cell lines and primary dendritic cells using flow cytometry, cell-based enzyme-linked immunosorbent assay and western blotting. We confirmed that FL-protective rs2647012-linked variants, in high linkage disequilibrium with the extended haplotype DRB1*15:01-DQA1*01:02-DQB1*06:02, correlate with increased HLA-DQB1 expression. This association remained significant at the protein level and was reproducible across different cell types. We also found that differences in HLA-DQB1 expression were not related to changes in activation markers or class II, major histocompatibility complex, transactivator expression, suggesting the role of an alternative regulatory mechanism. However, functional analysis using RegulomeDB did not reveal any relevant regulatory candidates. Future studies should focus on the clinical relevance of increased HLA-DQB1 protein expression facilitating tumor cell removal through increased immune surveillance.

Indexed as

Cells, CulturedDendritic CellsGene FrequencyGenetic Predisposition to DiseaseHaplotypesHLA-DQ beta-ChainsHumansLinkage DisequilibriumLipopolysaccharidesLymphocyte ActivationLymphoma, FollicularPolymorphism, Single NucleotideQuantitative Trait LociHLA-DQB1 antigenHLA-DQ beta-ChainsLipopolysaccharides

Identifiers

PMID24304973
PMCPMC6279234
OpenAlexW2039694244

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.