Trial reportBMC research notes2013
Foods with added fiber improve stool frequency in individuals with chronic kidney disease with no impact on appetite or overall quality of life.
Trial report in BMC research notes, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01842087 (An Investigation Into Pulse Fiber Fermentation and Nitrogen Excretion in Patients With Chronic Renal Failure), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Investigation Into Pulse Fiber Fermentation and Nitrogen Excretion in Patients With Chronic Renal Failure
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Pooled it
- Evaluation of Constipation and Quality of Life Among Individuals Undergoing Hemodialysis: A Single-Center Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Chronic Kidney Disease Diets for Kidney Failure Prevention: Insights from the IL-11 Paradigm.Nutrients · 2024Review
- Bowel Health in U.S. Shift Workers: Insights from a Cross-Sectional Study (NHANES).International journal of environmental research and public health · 2022Article
- Fiber intake and health in people with chronic kidney disease.Clinical kidney journal · 2022Article
- A high-fibre personalised dietary advice given via a web tool reduces constipation complaints in adults.Journal of nutritional science · 2022Article
- Development and validation of the FiberScreen: A short questionnaire to screen fibre intake in adults.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2021Article
- Gastrointestinal Tolerance and Microbiome Response to Snacks Fortified with Pea Hull Fiber: A Randomized Trial in Older Adults.Current developments in nutrition · 2020Article
- Review
- Dietary Fiber and Gut Microbiota in Renal Diets.Nutrients · 2019Review
- Nutritional treatment of advanced CKD: twenty consensus statements.Journal of nephrology · 2018Article
- Diet and enteral nutrition in patients with chronic kidney disease not on dialysis: a review focusing on fat, fiber and protein intake.Journal of nephrology · 2017Review
- Review
- Association between plasma endocannabinoids and appetite in hemodialysis patients: A pilot study.Nutrition research (New York, N.Y.) · 2016Article
- Cholesterol Metabolism in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFiber intake may be low in individuals with chronic kidney disease (CKD) due to diet restriction and/or poor appetite associated with uremic symptoms, contributing to constipation and reduced quality of life. This report describes the effects of foods with added fiber on gastrointestinal function and symptoms, clinical markers, and quality of life in CKD patients.
findingsAdults with CKD (n = 15; 9 F, 6 M; 66 ± 15 y) were provided with cereal, cookies and snack bars without added fiber for 2 weeks, followed by similar foods providing 23 g/d of added fiber for 4 weeks, to incorporate into their usual diets. Participants completed the Kidney Disease Quality of Life (KDQOL-36) questionnaire, the Simplified Nutritional Appetite Questionnaire (SNAQ) and the Epworth Sleepiness Scale (ESS) bi-weekly, the Gastrointestinal Symptom Rating Scale (GSRS) weekly, and daily stool frequency and compliance. Control and intervention serum cholesterol and glucose were assessed. Providing 23 g/d of added fiber increased stool frequency (1.3 ± 0.2 to 1.6 ± 0.2 stools/d; P = 0.02), decreased total cholesterol (175 ± 12 to 167 ± 11 mg/dL; P = 0.02) and improved TC:HDL ratio (4.0 ± 0.3 to 3.7 ± 0.2; P = 0.02). GSRS and SNAQ scores did not change, but SNAQ scores suggested poor appetite in 7 participants with or without added fiber. KDQOL Mental Health Composite decreased from 53 ± 2 to 48 ± 2 (P = 0.01) while Physical Health Composite increased from 31 ± 2 to 35 ± 3 (P = 0.02), with no change in overall QOL. The ESS score decreased from 10 ± 1 to 8 ± 1 (P = 0.04).
conclusionConsuming foods with added fiber may be an effective means of increasing fiber intakes, improving stool frequency, and lipid profile in individuals with CKD.
trial registrationClinicalTrials.gov, # NCT01842087.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.