ArticleThe ISME journal2014
Host immune responses accelerate pathogen evolution.
Article in The ISME journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Genomic Biosurveillance of the Kiwifruit Pathogen Pseudomonas syringae pv. actinidiae Biovar 3 Reveals Adaptation to Selective Pressures in New Zealand Orchards.Molecular plant pathology · 2025Article
- Navigating Host Immunity and Concurrent Ozone Stress: Strain-Resolved Metagenomics Reveals Maintenance of Intraspecific Diversity and Genetic Variation inEvolutionary applications · 2025Article
- Pathotyping Citrus Ornamental Relatives withMicroorganisms · 2022Article
- Convergent Rewiring of the Virulence Regulatory Network Promotes Adaptation of Ralstonia solanacearum on Resistant Tomato.Molecular biology and evolution · 2021Article
- Mapping the adaptive landscape of a major agricultural pathogen reveals evolutionary constraints across heterogeneous environments.The ISME journal · 2021Article
- Parallel Evolution of Enhanced Biofilm Formation and Phage-Resistance inMicroorganisms · 2021Article
- Consequences of adaptation of TAL effectors on host susceptibility to Xanthomonas.PLoS genetics · 2021Article
- The immunity of Meiwa kumquat against Xanthomonas citri is associated with a known susceptibility gene induced by a transcription activator-like effector.PLoS pathogens · 2020Article
- Comparative genomic analyses reveal the features for adaptation to nematodes in fungi.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Grapevine rootstocks shape underground bacterial microbiome and networking but not potential functionality.Microbiome · 2018Article
- Novel Plastid-Nuclear Genome Combinations Enhance Resistance to Citrus Canker in Cybrid Grapefruit.Frontiers in plant science · 2018Article
- Adaptation of the pathogen, Pseudomonas syringae, during experimental evolution on a native vs. alternative host plant.Molecular ecology · 2017Article
- Enhanced in planta Fitness through Adaptive Mutations in EfpR, a Dual Regulator of Virulence and Metabolic Functions in the Plant Pathogen Ralstonia solanacearum.PLoS pathogens · 2016Article
- A Borrelia burgdorferi Surface-Exposed Transmembrane Protein Lacking Detectable Immune Responses Supports Pathogen Persistence and Constitutes a Vaccine Target.The Journal of infectious diseases · 2016Article
- Molecular mechanisms underlying the emergence of bacterial pathogens: an ecological perspective.Molecular plant pathology · 2016Review
- Positive selection is the main driving force for evolution of citrus canker-causing Xanthomonas.The ISME journal · 2015Article
- Effector triggered manipulation of host immune response elicited by different pathotypes of Escherichia coli.Virulence · 2014Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathogens face a hostile and often novel environment when infecting a new host, and adaptation is likely to be an important determinant of the success in colonization and establishment. We hypothesized that resistant hosts will impose stronger selection on pathogens than susceptible hosts, which should accelerate pathogen evolution through selection biased toward effector genes. To test this hypothesis, we conducted an experimental evolution study on Xanthomonas citri subsp. citri (Xcc) in a susceptible plant species and a resistant plant species. We performed 55 rounds of repeated reinoculation of Xcc through susceptible host grapefruit (isolates G1, G2, G3) and resistant host kumquat (isolates K1, K2, K3). Consequently, only K1 and K3 isolates lost their ability to elicit a hypersensitive response (HR) in kumquat. Illumina sequencing of the parental and descendant strains P, G1, G2, G3, K1, K2 and K3 revealed that fixed mutations were biased toward type three secretion system effectors in isolates K1 and K3. Parallel evolution was observed in the K1 and K3 strains, suggesting that the mutations result from selection rather than by random drift. Our results support our hypothesis and suggest that repeated infection of resistant hosts by pathogens should be prevented to avoid selecting for adaptive pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.