ArticleCardiovascular ultrasound2013
Left ventricular strain distribution in healthy dogs and in dogs with tachycardia-induced dilated cardiomyopathy.
Article in Cardiovascular ultrasound, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Characterization of global and regional left heart function using advanced echocardiography following intravenous administration of pimobendan in awake dogs.Frontiers in veterinary science · 2026Article
- Reference Intervals for Conventional Transthoracic Echocardiography and Two-Dimensional Speckle Tracking Echocardiography-Derived Strain Values in the Dutch Sheepdog ('Schapendoes').Animals : an open access journal from MDPI · 2025Article
- Speckle-Tracking Echocardiography in Dogs: Evaluating Imaging Parameters and Methodological Variability in Global Longitudinal Strain Assessment.Animals : an open access journal from MDPI · 2025Article
- Changes in echocardiographic indices and left ventricular strain values by two-dimensional speckle-tracking echocardiography following pre-anesthetic oral pimobendan administration compared with intravenous pimobendan in dogs.Frontiers in veterinary science · 2024Article
- Association between cardiovascular risk factors and left ventricular strain distribution in patients without previous cardiovascular disease.Journal of echocardiography · 2022Article
- Assessment of Cardiotoxicity after a Single Dose of Combretastatin A4-Phosphate in Dogs Using Two-Dimensional Speckle-Tracking Echocardiography.Animals : an open access journal from MDPI · 2022Article
- A Case of a Small-Breed Dog with Diet-Related Dilated Cardiomyopathy Showing Marked Improvements in Cardiac Morphology and Function after Dietary Modification.Veterinary sciences · 2022Article
- Evaluation of Left Ventricular Function in Healthy Retrievers Using Standard and 2D Speckle-Tracking Echocardiography.Veterinary sciences · 2022Article
- Tissue motion annular displacement to assess the left ventricular systolic function in healthy cats.Veterinary research communications · 2022Article
- Role of Two-Dimensional Speckle-Tracking Echocardiography in Early Detection of Left Ventricular Dysfunction in Dogs.Animals : an open access journal from MDPI · 2021Review
- Speckle tracking echocardiography in cats with preclinical hypertrophic cardiomyopathy.Journal of veterinary internal medicine · 2019Article
- Distribution pattern of left-ventricular myocardial strain analyzed by a cine MRI based deformation registration algorithm in healthy Chinese volunteers.Scientific reports · 2017Article
- Phase analysis of gated blood pool SPECT for multiple stress testing assessments of ventricular mechanical dyssynchrony in a tachycardia-induced dilated cardiomyopathy canine model.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Echocardiographic Assessment of Cardiac Function by Conventional and Speckle-Tracking Echocardiography in Dogs with Patent Ductus Arteriosus.Journal of veterinary internal medicine · 2016Article
- Dilated Cardiomyopathy: Normalized Multiparametric Myocardial Strain Predicts Contractile Recovery.The Annals of thoracic surgery · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, left ventricular (LV) strain distribution pattern has been assessed in several cardiac disease states. Tachycardia-induced cardiomyopathy (TIC) is an animal model of non-ischemic cardiomyopathy well characterized in terms of global LV dysfunction but with poor understanding of regional variability in LV function. We hypothesized that TIC induces specific changes in LV strain distribution pattern.
methodsTwenty five adult mongrel conscious dogs were trained to lie down calmly for echocardiography. In seven selected dogs, we implanted pacing system for TIC induction under general anesthesia. We measured LV geometry and function, strains, and torsion before and after the development of TIC in awake non-sedated state.
resultsIn 25 healthy dogs, all three types of normal strain significantly increased from base to apex (p <0.05), while a definite and recognizable twist could be measured due to presence of shear strain. In 7 dogs with TIC, marked changes in LV mechanics occurred throughout the cardiac cycle, resulting in decrease of strain (p <0.001), twist (p <0.05), and negative peak twist rate (p <0.05). Interestingly, the relative decrease of strain due to TIC was more pronounced in the apex (p < 0.001), with the radial strain decreasing the most (p < 0.05).
conclusionTIC is accompanied by decreased systolic LV strain and twist deformation, as well as loss of early diastolic recoil. In addition, the decrease of strain was more profound in the apex. This "reverse" distribution of LV strain may help us understand LV dysfunction in the presence of nonischemic etiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.