ArticleEpilepsia2013
Neurobehavioral comorbidities of pediatric epilepsies are linked to thalamic structural abnormalities.
Article in Epilepsia, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Shared Genetic Architecture Between Common Epilepsies and Subcortical Brain Volumes Is Associated With Cognition and Mental Health.CNS neuroscience & therapeutics · 2026Article
- Multidimensional dataset for cognitive assessment, sMRI, and rsfMRI in common benign epileptic children.Scientific data · 2025Article
- Relation of Brain Perfusion Patterns to Sudden Unexpected Death Risk Stratification: A Study in Drug Resistant Focal Epilepsy.Behavioral sciences (Basel, Switzerland) · 2022Article
- Subcortical nuclei volumes are associated with cognition in children post-convulsive status epilepticus: Results at nine years follow-up.Epilepsy & behavior : E&B · 2020Article
- Cognitive Function in Genetic Generalized Epilepsies: Insights From Neuropsychology and Neuroimaging.Frontiers in neurology · 2020Review
- Childhood epilepsies: What should a pediatrician know?Neurosciences (Riyadh, Saudi Arabia) · 2017Review
- A New MRI-Based Pediatric Subcortical Segmentation Technique (PSST).Neuroinformatics · 2016Article
- Epilepsy, cognitive deficits and neuroanatomy in males with ZDHHC9 mutations.Annals of clinical and translational neurology · 2015Article
- Quantifying the deficit-imaging neurobehavioural impairment in childhood epilepsy.Quantitative imaging in medicine and surgery · 2015Review
- Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome.Neurobiology of disease · 2015Article
- Behavioral Abnormalities in Lagotto Romagnolo Dogs with a History of Benign Familial Juvenile Epilepsy: A Long-Term Follow-Up Study.Journal of veterinary internal medicineArticle
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Authors and funding
9 authors.
Funding
Abstract
purposeNeurobehavioral comorbidities are common in pediatric epilepsy with enduring adverse effects on functioning, but their neuroanatomic underpinning is unclear. Striatal and thalamic abnormalities have been associated with childhood-onset epilepsies, suggesting that epilepsy-related changes in the subcortical circuit might be associated with the comorbidities of children with epilepsy. We aimed to compare subcortical volumes and their relationship with age in children with complex partial seizures (CPS), childhood absence epilepsy (CAE), and healthy controls (HC). We examined the shared versus unique structural-functional relationships of these volumes with behavior problems, intelligence, language, peer interaction, and epilepsy variables in these two epilepsy syndromes.
methodsWe investigated volumetric differences of caudate, putamen, pallidum, and thalamus in children with CPS (N = 21), CAE (N = 20), and HC (N = 27). Study subjects underwent structural magnetic resonance imaging (MRI), intelligence, and language testing. Parent-completed Child Behavior Checklists provided behavior problem and peer interaction scores. We examined the association of age, intelligence quotient (IQ), language, behavioral problems, and epilepsy variables with subcortical volumes that were significantly different between the children with epilepsy and HC. KEY
findingsBoth children with CPS and CAE exhibited significantly smaller left thalamic volume compared to HC. In terms of developmental trajectory, greater thalamic volume was significantly correlated with increasing age in children with CPS and CAE but not in HC. With regard to the comorbidities, reduced left thalamic volumes were related to more social problems in children with CPS and CAE. Smaller left thalamic volumes in children with CPS were also associated with poor attention, lower IQ and language scores, and impaired peer interaction. SIGNIFICANCE: Our study is the first to directly compare and detect shared thalamic structural abnormalities in children with CPS and CAE. These findings highlight the vulnerability of the thalamus and provide important new insights on its possible role in the neurobehavioral comorbidities of childhood-onset epilepsy.
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