ArticleJournal of clinical periodontology2014
Comparative analysis of gingival tissue antigen presentation pathways in ageing and periodontitis.
Article in Journal of clinical periodontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Influence of Natural Killer Cells and Natural Killer T Cells on Periodontal Disease: A Systematic Review of the Current Literature.International journal of molecular sciences · 2020Pooled it
- Obstructive Sleep Apnea Associated with Periodontitis: Evidence from Mendelian Randomization and Salivary Proteomics.Journal of proteome research · 2026Article
- Obesity and cathepsin S in periodontal health and disease: A prospective clinical observational study.Acta odontologica Scandinavica · 2025Observational
- Featured Immune Characteristics of Periodontitis and Primary Sjögren's Syndrome Revealed by Single-Cell Transcriptome Analyses.Journal of cellular and molecular medicine · 2025Article
- Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging.Protein & cell · 2024Article
- Transcriptional Signatures and Network-Based Approaches Identified Master Regulators Transcription Factors Involved in Experimental Periodontitis Pathogenesis.International journal of molecular sciences · 2023Article
- Gingival transcriptomic patterns of macrophage polarization during initiation, progression, and resolution of periodontitis.Clinical and experimental immunology · 2023Article
- DAMPs and alarmin gene expression patterns in aging healthy and diseased mucosal tissues.Frontiers in oral health · 2023Article
- A role of inflammaging in aortic aneurysm: new insights from bioinformatics analysis.Frontiers in immunology · 2023Article
- Transcriptome Profiling of Duodenum Reveals the Importance of Boron Supplementation in Modulating Immune Activities in Rats.Biological trace element research · 2022Article
- Comparative Analysis of Gene Expression Patterns for Oral Epithelial Cell Functions in Periodontitis.Frontiers in oral health · 2022Article
- Article
- Gingival Transcriptome of Innate Antimicrobial Factors and the Oral Microbiome With Aging and Periodontitis.Frontiers in oral health · 2022Article
- Gingival transcriptomics of follicular T cell footprints in progressing periodontitis.Clinical and experimental immunology · 2021Article
- Transcriptomic phases of periodontitis lesions using the nonhuman primate model.Scientific reports · 2021Article
- Oral Microbiome and Gingival Gene Expression of Inflammatory Biomolecules With Aging and Periodontitis.Frontiers in oral health · 2021Article
- Oral Microbiome and Gingival Tissue Apoptosis and Autophagy Transcriptomics.Frontiers in immunology · 2020Article
- Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis.Evidence-based complementary and alternative medicine : eCAM · 2020Review
- Periodontal disease susceptible matrilines in the Cayo Santiago Macaca mulatta macaques.Journal of periodontal research · 2019Article
- Comparative analysis of expression of microbial sensing molecules in mucosal tissues with periodontal disease.Immunobiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
aimGingival tissues of periodontitis lesions contribute to local elevations in mediators, including both specific T cell and antibody immune responses to oral bacterial antigens. Thus, antigen processing and presentation activities must exist in these tissues to link antigen-presenting cells with adaptive immunity. We hypothesized that alterations in the transcriptome of antigen processing and presentation genes occur in ageing gingival tissues and that periodontitis enhances these differences reflecting tissues less capable of immune resistance to oral pathogens. MATERIALS AND
methodsRhesus monkeys (n = 34) from 3 to 23 years of age were examined. A buccal gingival sample from healthy or periodontitis sites was obtained, total RNA isolated, and microarray analysis was used to describe the transcriptome.
resultsThe results demonstrated increased transcription of genes related to the MHC class II and negative regulation of NK cells with ageing in healthy gingival tissues. In contrast, both adult and ageing periodontitis tissues showed decreased transcription of genes for MHC class II antigens, coincident with up-regulation of MHC class I-associated genes.
conclusionThese transcriptional changes suggest a response of healthy ageing tissues through the class II pathway (i.e. endocytosed antigens) and altered responses in periodontitis that could reflect host-associated self-antigens or targeting cytosolic intracellular microbial pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.