ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2013
Analyzing disease-associated protein structures with visual analytics.
Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Protein function is related to protein structure, and understanding disease-associated structural changes is critical both to understanding protein-mediated illness and to developing clinical therapies. We have developed a visual analytics tool called ContactWalker that uses molecular dynamics simulations to investigate the structural and physical differences between wild type and disease-associated protein structures. This tool has been used successfully to characterize the effects of the disease ataxia with vitamin E deficiency (AVED). We are now beginning to investigate mutations to other disease-associated proteins including the tumor suppressor protein p53.
Identifiers
24303293PMC3814492W268728690What OpenQuestion holds
Registered trials
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