ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2013
How Cytokines Co-occur across Rickettsioses Patients: From Bipartite Visual Analytics to Mechanistic Inferences of a Cytokine Storm.
Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- The Pre-Adaptation of a Stroke-Specific Self-Management Program Among Older Adults.Journal of aging and health · 2023Article
- Leptospirosis and rickettsiosis, a diagnostic challenge for febrile syndrome in endemic areasBiomedica : revista del Instituto Nacional de Salud · 2021Article
- Methylation differences reveal heterogeneity in preterm pathophysiology: results from bipartite network analyses.Journal of perinatal medicine · 2018Review
- Review
- Heterogeneity within and across Pediatric Pulmonary Infections: From Bipartite Networks to At-Risk Subphenotypes.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2014Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Several intersecting host, vector, and environmental factors have led to a re-emergence of rickettsial diseases such as Mediterranean Spotted Fever (MSF), and Dermacentor spp.-borne necrosis-erythema lymphadenopathy (DEBONEL). Some rickettsiae produce diffuse endothelial infection and systemic microvascular leakage leading in some cases to high morbidity and mortality. Unfortunately, little is known about the molecular pathways triggered by these diseases in humans. We therefore analyzed how candidate cytokines co-occur across acutely-ill patients with either a localized (DEBONEL), or a systemic (MSF) form of rickettsiosis, using bipartite visual analytics. The results revealed a network core consisting of a small set of MSF patients exhibiting high expressions of cytokines implicated in microvascular leakage, endothelial repair, and pro-inflammatory immune responses, and a network periphery consisting of a mixture of MSF and DEBONEL patients with relatively lower overall cytokine expressions. These results provide evidence of pathways triggered by rickettsiae in humans, and a testable hypothesis for the mechanisms in a rickettsia-induced cytokine storm with the translational goal of identifying therapeutic targets.
Identifiers
24303287PMC3814500W241432103What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.