ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2013
ADEpedia 2.0: Integration of Normalized Adverse Drug Events (ADEs) Knowledge from the UMLS.
Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Evaluating MedDRA-to-ICD terminology mappings.BMC medical informatics and decision making · 2024Article
- Leveraging the UMLS As a Data Standard for Rare Disease Data Normalization and Harmonization.Methods of information in medicine · 2020Article
- ADEpedia-on-OHDSI: A next generation pharmacovigilance signal detection platform using the OHDSI common data model.Journal of biomedical informatics · 2019Article
- Article
- Drug-drug interaction discovery and demystification using Semantic Web technologies.Journal of the American Medical Informatics Association : JAMIA · 2017Article
- A Querying Method over RDF-ized Health Level Seven v2.5 Messages Using Life Science Knowledge Resources.JMIR medical informatics · 2016Article
- Ontology-based collection, representation and analysis of drug-associated neuropathy adverse events.Journal of biomedical semantics · 2016Article
- Exploring adverse drug events at the class level.Journal of biomedical semantics · 2015Article
- Mining severe drug-drug interaction adverse events using Semantic Web technologies: a case study.BioData mining · 2015Article
- Standardizing adverse drug event reporting data.Journal of biomedical semantics · 2014Article
- A Framework of Knowledge Integration and Discovery for Supporting Pharmacogenomics Target Predication of Adverse Drug Events: A Case Study of Drug-Induced Long QT Syndrome.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A standardized Adverse Drug Events (ADEs) knowledge base that encodes known ADE knowledge can be very useful in improving ADE detection for drug safety surveillance. In our previous study, we developed the ADEpedia that is a standardized knowledge base of ADEs based on drug product labels. The objectives of the present study are 1) to integrate normalized ADE knowledge from the Unified Medical Language System (UMLS) into the ADEpedia; and 2) to enrich the knowledge base with the drug-disorder co-occurrence data from a 51-million-document electronic medical records (EMRs) system. We extracted 266,832 drug-disorder concept pairs from the UMLS, covering 14,256 (1.69%) distinct drug concepts and 19,006 (3.53%) distinct disorder concepts. Of them, 71,626 (26.8%) concept pairs from UMLS co-occurred in the EMRs. We performed a preliminary evaluation on the utility of the UMLS ADE data. In conclusion, we have built an ADEpedia 2.0 framework that intends to integrate known ADE knowledge from disparate sources. The UMLS is a useful source for providing standardized ADE knowledge relevant to indications, contraindications and adverse effects, and complementary to the ADE data from drug product labels. The statistics from EMRs would enable the meaningful use of ADE data for drug safety surveillance.
Identifiers
24303245PMC3845793W1508688What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.