ReviewThrombosis2013
Anticoagulation for prosthetic valves.
Review in Thrombosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- [Cardiac surgery in the elderly].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2017Pooled it
- Safety and Use of Anticoagulation After Aortic Valve Replacement With Bioprostheses: A Meta-Analysis.Circulation. Cardiovascular quality and outcomes · 2016Pooled it
- Smaller Bioprosthetic Valves May Be Associated with Worse Clinical Outcomes and Reduced Freedom from Reoperation in sAVR.Journal of cardiovascular development and disease · 2025Review
- Drug-Drug Interaction of Warfarin and Doxycycline Leading to a Large Rectus Sheath Hematoma.Cureus · 2025Article
- Clinical Outcomes and Risk Factors of Heart Transplantation Patients Experiencing Gastrointestinal Bleeding.Biomedicines · 2024Article
- Article
- Mechanical prosthetic valve thrombosis in current era: 5-year follow-up.Indian journal of thoracic and cardiovascular surgery · 2021Article
- Effect of Self-Management Program on Self-efficacy and Medication Adherence in Patients with Mechanical Heart Valve: a Randomized Clinical Trial.Journal of caring sciences · 2019Article
- Follow-up and management of valvular heart disease patients with prosthetic valve: a clinical practice guideline for Indian scenario.Indian journal of thoracic and cardiovascular surgery · 2019Article
- Mechanical aortic valve without anticoagulation for 33 years in a Yemeni man: a case report.Journal of medical case reports · 2016Article
- Advances in the management of severe aortic stenosis.Irish journal of medical science · 2016Review
- Endothelial retention and phenotype on carbonized cardiovascular implant surfaces.Biomaterials · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantation of prosthetic valve requires consideration for anticoagulation. The current guideline recommends warfarin on all mechanical valves. Dabigatran is the new generation anticoagulation medication which is taken orally and does not require frequent monitoring. This drug is approved for treatment for atrial fibrillation and venous thromboembolism, but the latest large trial showed that this drug increases adverse events when used for mechanical valve anticoagulation. On-X valve is the new generation mechanical valve which is considered to require less anticoagulation due to its flow dynamics. The latest study showed that lower anticoagulation level lowers the incidence of bleeding, while the risk of thromboembolism and thrombosis remained the same. Anticoagulation poses dilemma in cases such as pregnancy and major bleeding event. During pregnancy, warfarin can be continued throughout pregnancy and switched to heparin derivative during 6-12 weeks and >36 weeks of gestation. Warfarin can be safely started after 1-2 weeks of discontinuation following major bleeding episode.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.