ArticleJournal of obesity2013
Effects of Roux-en-Y gastric bypass on fasting and postprandial levels of the inflammatory markers YKL-40 and MCP-1 in patients with type 2 diabetes and glucose tolerant subjects.
Article in Journal of obesity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis.Obesity surgery · 2020Pooled it
- Systemic Inflammation in Severe Obese Patients Undergoing Surgery for Obesity and Weight-Related Diseases.Obesity surgery · 2018Trial
- Changes in Inflammatory Markers Following Bariatric Surgery and the Impact of the Surgical Procedure: A 12-Month Longitudinal Study.Obesity surgery · 2025Article
- The Effect of Bariatric Surgery on Circulating Levels of Monocyte Chemoattractant Protein-1: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Article
- Differences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss.Journal of clinical medicine · 2022Article
- Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy.International journal of obesity (2005) · 2020Article
- Bariatric surgery reduces CD36-bearing microvesicles of endothelial and monocyte origin.Nutrition & metabolism · 2018Article
- Effects of Roux-en-Y gastric bypass on fasting and postprandial inflammation-related parameters in obese subjects with normal glucose tolerance and in obese subjects with type 2 diabetes.Diabetology & metabolic syndrome · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT).
methodsTen obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB.
resultsFasting state MCP-1 levels decreased after RYGB in both groups (P values < 0.0001) whereas fasting YKL-40 levels were unchanged (P values ≥ 0.120). Postprandial MCP-1 levels showed a tendency towards a decrease on most study days; however, the changes were only significant at 1 week (P = 0.001) and 1 yr (P < 0.0001) in the T2D group and at 3 mo after RYGB in the NGT group (P = 0.009). YKL-40 levels showed a slight, postprandial suppression on all study days in the T2D group (all P values ≤ 0.021).
conclusionsFasting MCP-1 levels, but not YKL-40 levels, decrease after RYGB in subjects with T2D and NGT. Postprandial changes of inflammatory markers are discrete and inconsistent.
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