ArticlePhysiological reports2013
Manipulation of arterial stiffness, wave reflections, and retrograde shear rate in the femoral artery using lower limb external compression.
Article in Physiological reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Trial
- Lower limb blood flow responses during higher- and lower-load bilateral leg press exercise.Experimental physiology · 2026Article
- Mechanisms of Central Hemodynamic Changes Due to Limb Tourniquets and Cuffs: Mathematical Modeling Studies with Implications for Cardiopulmonary Resuscitation.Annals of biomedical engineering · 2026Article
- When Load Does not Tell the Whole Story: Acute Effects of Effort Matched Resistance Training Protocols on Arterial Stiffness.European journal of sport science · 2026Article
- One Step Back from Bedside to the Bench-How Do Different Arterial Stiffness Parameters Behave in Relation to Peripheral Resistance?Diagnostics (Basel, Switzerland) · 2023Article
- Influence of sprint exercise on aortic pulse wave velocity and femoral artery shear patterns.European journal of applied physiology · 2020Article
- Acute Changes in Carotid-Femoral Pulse-Wave Velocity Are Tracked by Heart-Femoral Pulse-Wave Velocity.Frontiers in cardiovascular medicine · 2020Article
- Effect of external compression on femoral retrograde shear and microvascular oxygenation in exercise trained and recreationally active young men.European journal of applied physiology · 2019Article
- Cerebral hemodynamics and intracranial aneurysms: Reflecting on pipeline embolization devices.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2018Article
- Impact of Aging on Endurance and Neuromuscular Physical Performance: The Role of Vascular Senescence.Sports medicine (Auckland, N.Z.) · 2017Review
- Endogenous endothelin-1 and femoral artery shear rate: impact of age and implications for atherosclerosis.Journal of hypertension · 2016Article
- Functional aortic stiffness: role of CD4(+) T lymphocytes.Frontiers in physiology · 2015Article
- Article
- Effect of acute resistance exercise on carotid artery stiffness and cerebral blood flow pulsatility.Frontiers in physiology · 2014Article
- Hemodynamic correlates of late systolic flow velocity augmentation in the carotid artery.International journal of hypertension · 2013Article
- Effect of Acute Resistance Exercise and Resistance Exercise Training on Central Pulsatile Hemodynamics and Large Artery Stiffness: Part I.Pulse (Basel, Switzerland)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure of the arterial wall to retrograde shear acutely leads to endothelial dysfunction and chronically contributes to a proatherogenic vascular phenotype. Arterial stiffness and increased pressure from wave reflections are known arbiters of blood flow in the systemic circulation and each related to atherosclerosis. Using distal external compression of the calf to increase upstream retrograde shear in the superficial femoral artery (SFA), we examined the hypothesis that changes in retrograde shear are correlated with changes in SFA stiffness and pressure from wave reflections. For this purpose, a pneumatic cuff was applied to the calf and inflated to 0, 35, and 70 mmHg (5 min compression, randomized order, separated by 5 min) in 16 healthy young men (23 ± 1 years of age). Doppler ultrasound and wave intensity analysis was used to measure SFA retrograde shear rate, reflected pressure wave intensity (negative area [NA]), elastic modulus (Ep), and a single-point pulse wave velocity (PWV) during acute cuff inflation. Cuff inflation resulted in stepwise increases in retrograde shear rate (P < 0.05 for main effect). There were also significant cuff pressure-dependent increases in NA, Ep, and PWV across conditions (P < 0.05 for main effects). Change in NA, but not Ep or PWV, was associated with change in retrograde shear rate across conditions (P < 0.05). In conclusion, external compression of the calf increases retrograde shear, arterial stiffness, and pressure from wave reflection in the upstream SFA in a dose-dependent manner. Wave reflection intensity, but not arterial stiffness, is correlated with changes in peripheral retrograde shear with this hemodynamic manipulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.