ArticlePhysiological reports2013
Pharmacological analysis of dopamine modulation in the Drosophila melanogaster larval heart.
Article in Physiological reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 29 citations in OpenAlex.
- A mechanosensitive vascular niche forProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Examining the effect of manganese on physiological processes: Invertebrate models.Comparative biochemistry and physiology. Toxicology & pharmacology : CBP · 2022Article
- Smoking flies: testing the effect of tobacco cigarettes on heart function ofBiology open · 2021Article
- The effects of tricaine mesylate on arthropods: crayfish, crab and Drosophila.Invertebrate neuroscience : IN · 2020Article
- Effects of inhibiting mTOR with rapamycin on behavior, development, neuromuscular physiology and cardiac function in larvalBiology open · 2019Article
- The Effects of Chloride Flux onMethods and protocols · 2019Article
- Dop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts.Nature communications · 2018Article
- Using optogenetics to assess neuroendocrine modulation of heart rate in Drosophila melanogaster larvae.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Modulatory effects on Drosophila larva hearts: room temperature, acute and chronic cold stress.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Optogenetic stimulation of Drosophila heart rate at different temperatures and Ca2+ concentrations.Physiological reports · 2016Article
- Pharmacological identification of cholinergic receptor subtypes on Drosophila melanogaster larval heart.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2016Article
- Two dopamine receptors play different roles in phase change of the migratory locust.Frontiers in behavioral neuroscience · 2015Article
- Pharmacological and genetic identification of serotonin receptor subtypes on Drosophila larval heart and aorta.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- Analysis of various physiological salines for heart rate, CNS function, and synaptic transmission at neuromuscular junctions in Drosophila melanogaster larvae.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
- 5-HT stimulation of heart rate in Drosophila does not act through cAMP as revealed by pharmacogenetics.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine (DA) and other neurotransmitters affect nonneuronal tissues in insects by circulating in the hemolymph. In several organisms, DA has been shown to modulate distinct aspects of cardiac function but the signal transduction pathways that mediate dopaminergic effects on the heart are not well characterized. Here, we used a semiintact Drosophila melanogaster larva preparation and drugs targeting DA receptors and canonical second messenger pathways to identify signaling cascades that mediate the effect of DA on a myogenic heart. DA has a positive chronotropic effect that is mimicked by SKF38393 (type-1 DA receptor agonist) and quinpirole (type-2 DA receptor agonist). SCH23390 and spiperone (type-1 and type-2 DA receptor antagonists) are moderately effective at inhibiting DA's effect. An adenylate cyclase inhibitor (SQ,22536) is also effective at blocking the stimulatory effect of DA but the drug has its own dose-dependent effect. Activation of protein kinase C with a diacylglycerol analog has a stimulatory effect on heart rate (HR). These results suggest that (1) both DA receptor subtypes are expressed in third instar larva cardiac myocytes to increase HR in response to rising levels of DA in the hemolymph, and (2) canonical second messenger pathways modulate HR in D. melanogaster larvae. Having these disparate signaling cascades converge toward a common modulatory function appears redundant, but in the context of multiple cardioactive chemicals this redundancy is likely to increase the fidelity of signal transduction.
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