ArticlePloS one2013
Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Prenatal nutrition supplementation and growth biomarkers in preadolescent Bangladeshi children: A birth cohort study.Maternal & child nutrition · 2022Trial
- Circulating Exosomal MicroRNA Profiles Associated with Heavy Metal Exposure and Short Stature in Children.International journal of molecular sciences · 2026Article
- Prenatal green space exposure and child's cognition: mediation by cord blood IGF1 in the ENVIRONAGE birth cohort.Environment international · 2025Article
- Associations Between Prenatal Blood Metals and Vitamins and Cord Blood Peptide Hormone Concentrations.Global reproductive health · 2023Article
- Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels.International journal of molecular sciences · 2021Review
- Article
- Analysis of pituitary transcriptomics indicates that lncRNAs are involved in the regulation of sheep estrus.Functional & integrative genomics · 2020Article
- Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children.Environmental health perspectives · 2019Article
- Article
- Embryonic arsenic exposure reduces intestinal cell proliferation and alters hepatic IGF mRNA expression in killifish (Fundulus heteroclitus).Journal of toxicology and environmental health. Part A · 2019Article
- Prenatal arsenic exposure is associated with increased plasma IGFBP3 concentrations in 9-year-old children partly via changes in DNA methylation.Archives of toxicology · 2018Article
- Assessment of Nutritional Status of Infants Living in Arsenic-Contaminated Areas in Bangladesh and Its Association with Arsenic Exposure.International journal of environmental research and public health · 2018Article
- Effects of Hair Metals on Body Weight in Iranian Children Aged 20 to 36 Months.Iranian journal of public health · 2017Article
- Embryonic-only arsenic exposure in killifish (Fundulus heteroclitus) reduces growth and alters muscle IGF levels one year later.Aquatic toxicology (Amsterdam, Netherlands) · 2017Article
- Low-Level Toxic Metal Exposure in Healthy Weaning-Age Infants: Association with Growth, Dietary Intake, and Iron Deficiency.International journal of environmental research and public health · 2017Article
- Environmental exposure and effects on health of children from a tobacco-producing region.Environmental science and pollution research international · 2017Article
- Arsenic Metabolism in Children Differs From That in Adults.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Maternal Micronutrient Supplementation and Long Term Health Impact in Children in Rural Bangladesh.PloS one · 2016Article
- The stunting syndrome in developing countries.Paediatrics and international child health · 2014Review
- Gestational Arsenic Trioxide Exposure Acts as a Developing Neuroendocrine-Disruptor by Downregulating Nrf2/PPARγ and Upregulating Caspase-3/NF-ĸB/Cox2/BAX/iNOS/ROS.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to inorganic arsenic (As) through drinking water during pregnancy is associated with lower birth size and child growth. The aim of the study was to assess the effects of As exposure on child growth parameters to evaluate causal associations. METHODOLOGY/
findingsChildren born in a longitudinal mother-child cohort in rural Bangladesh were studied at 4.5 years (n=640) as well as at birth (n=134). Exposure to arsenic was assessed by concurrent and prenatal (maternal) urinary concentrations of arsenic metabolites (U-As). Associations with plasma concentrations of insulin-like growth factor 1 (IGF-1), calcium (Ca), vitamin D (Vit-D), bone-specific alkaline phosphatase (B-ALP), intact parathyroid hormone (iPTH), and phosphate (PO4) were evaluated by linear regression analysis, adjusted for socioeconomic factor, parity and child sex. Child U-As (per 10 µg/L) was significantly inversely associated with concurrent plasma IGF-1 (β=-0.27; 95% confidence interval: -0.50, -0.0042) at 4.5 years. The effect was more obvious in girls (β=-0.29; -0.59, 0.021) than in boys, and particularly in girls with adequate height (β=-0.491; -0.97, -0.02) or weight (β=-0.47; 0.97, 0.01). Maternal U-As was inversely associated with child IGF-1 at birth (r=-0.254, P=0.003), but not at 4.5 years. There was a tendency of positive association between U-As and plasma PO4 in stunted boys (β=0.27; 0.089, 0.46). When stratified by % monomethylarsonic acid (MMA, arsenic metabolite) (median split at 9.7%), a much stronger inverse association between U-As and IGF-1 in the girls (β=-0.41; -0.77, -0.03) was obtained above the median split.
conclusionThe results suggest that As-related growth impairment in children is mediated, at least partly, through suppressed IGF-1 levels.
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