ArticlePloS one2013
Higher carbohydrate antigen 125 levels are associated with increased risk of coronary heart disease in elderly chinese: a population-based case-control study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Chronic Medical Conditions and CA125 Levels among Women without Ovarian Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Trial
- miR-203 Alleviates Myocardial Damage Caused by Acute Coronary Syndrome by Inhibiting CA125.Biochemical genetics · 2026Article
- Plasma CA125 Levels as a Predictor of Major Adverse Cardiac Events in Patients With Acute Coronary Syndrome: A Six-month Follow-up Study.Journal of the Saudi Heart Association · 2026Article
- Carbohydrate antigen 125 in congestive heart failure: ready for clinical application?Frontiers in oncology · 2023Review
- Factors associated with serum CA125 level in women without ovarian cancer in the United States: a population-based study.BMC cancer · 2022Article
- Endometriosis and cardiovascular disease.European heart journal open · 2022Article
- CA125 as a Marker of Heart Failure in the Older Women: Population-Based Analysis.Journal of clinical medicine · 2019Article
- Review
- Role of plasma levels of CA-125 in predicting outcome of primary PCI after acute myocardial infarction in male patients.Journal of cardiovascular and thoracic research · 2018Article
- Cancer antigen-125 plasma level as a biomarker of new-onset atrial fibrillation in postmenopausal women.Heart (British Cardiac Society) · 2017Article
- Cancer Antigen 125 is Associated with Length of Stay in Patients with Acute Heart Failure.Texas Heart Institute journal · 2017Article
- Clinical Value of Tumor Markers for Determining Cause of Pleural Effusion.Chinese medical journal · 2016Article
- Article
- A lack of association between theExperimental and therapeutic medicine · 2015Article
- Evaluation of CA125 and NT-proBNP values in patients undergoing transcatheter aortic valve implantation.Journal of geriatric cardiology : JGC · 2015Article
- Correlation of Serum Tumor Marker Carbohydrate Antigen 125 with Ankle-Brachial Index in Patients with Coronary Artery Disease.Journal of cardiovascular echographyArticle
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh carbohydrate antigen 125 (CA-125) level was reported to be associated with some cardiac dysfunctions, such as chronic heart failure, but the relationship between CA-125 level and coronary heart disease (CHD) risk remains unclear. The aim of this study was to explore the potential association in a Chinese older population.
methodsIn a population-based case-control study conducted in a Chinese older population, serum CA-125 levels were measured in 1177 diagnosed CHD patients and 3531 age and sex matched control subjects without CHD.
resultsSerum CA-125 level was significantly higher in CHD patients than controls (P < 0.001) with adjustment for age, gender, smoking, drinking, BMI, physical activity, hypertension, dyslipidemia, diabetes mellitus, medication history and family history of CHD and myocardial infarction. CHD risk was doubled (OR: 2.10, 95%CI: 1.69-2.60) among subjects in the highest quartile compared to those in the lowest quartile of CA-125 level (P trend < 0.001). Furthermore, CA-125 levels were associated with CHD risks in subjects with age over 60 years (OR: 2.19, 95%CI: 1.75-2.73), current smokers (OR: 2.29, 95%CI: 1.50-3.49), current drinkers (OR: 2.35, 95%CI: 1.57-3.53) and subjects with hypertension (OR: 2.04, 95%CI: 1.71-2.43).
conclusionsElevated serum CA-125 level might be associated with increased risk of coronary heart disease in the Chinese older population. Further investigations are needed to identify the possible biological role of CA-125 in CHD development in the future.
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