ArticlePloS one2013
Immunization using GroEL decreases Clostridium difficile intestinal colonization.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Immune Aspects of Clostridioides difficile Infection and Vaccine Development.Infectious disease clinics of North America · 2025Review
- Detection ofVirulence · 2025Article
- Whole-Genome Sequencing of Blood-Isolated Lactobacillus johnsonii in Thailand: Clinical Implications and Public Health Relevance.The American journal of case reports · 2025Article
- Anti-Inflammatory Function Analysis ofBiotech (Basel (Switzerland)) · 2025Article
- Genomic study of EuropeanMicrobial genomics · 2024Article
- Immunization Strategies Against Clostridioides difficile.Advances in experimental medicine and biology · 2024Review
- Mucosal Vaccination Strategies againstVaccines · 2023Review
- Non-Toxin-BasedPathogens (Basel, Switzerland) · 2023Article
- Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections.NPJ vaccines · 2022Article
- Towards Development of a Non-ToxigenicPharmaceutics · 2022Article
- Immunoinformatics Approach Toward the Introduction of a Novel Multi-Epitope Vaccine AgainstFrontiers in immunology · 2022Article
- Immunoproteomic analysis of Clostridium botulinum type B secretome for identification of immunogenic proteins against botulism.Biotechnology letters · 2021Article
- Article
- Host Immune Responses toFrontiers in microbiology · 2021Review
- Comparative Whole Genome Sequence Analysis and Biological Features ofFrontiers in microbiology · 2021Article
- Inhibitory Effect of Ursodeoxycholic Acid onFrontiers in microbiology · 2018Article
- TargetingFrontiers in microbiology · 2018Review
- Lineage structure of Streptococcus pneumoniae may be driven by immune selection on the groEL heat-shock protein.Scientific reports · 2017Article
- Clostridium difficile flagellin FliC: Evaluation as adjuvant and use in a mucosal vaccine against Clostridium difficile.PloS one · 2017Article
- Characteristics of the Clostridium difficile cell envelope and its importance in therapeutics.Microbial biotechnology · 2017Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clostridium difficile is a pathogen which is responsible for diarrhea and colitis, particularly after treatment with antibiotics. Clinical signs are mainly due to two toxins, TcdA and TcdB. However, the first step of pathogenesis is the colonization process. We evaluated C. difficile surface proteins as vaccine antigens in the hamster model to prevent intestinal colonization. This vaccination induced a partial protection of hamsters against death after a C. difficile challenge. A proteomic analysis of animal sera allowed us to identify proteins which could be responsible for the protection observed. Among these proteins, we identified the GroEL heat shock protein. To confirm the role of the specific GroEL antibodies in the delayed C. difficile colonization of hamsters, we performed an immunization assay in a mouse model. After intranasal immunization with the recombinant protein GroEL, we observed a lower C. difficile intestinal colonization in the immunized group as compared to the control group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.