ReviewFrontiers in immunology2013
Late steps in secretory lysosome exocytosis in cytotoxic lymphocytes.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Collagen fibril formation at the plasma membrane occurs independently from collagen secretion.Wellcome open research · 2025Article
- Recycling machinery of integrin coupled with focal adhesion turnover via RAB11-UNC13D-FAK axis for migration of pancreatic cancer cells.Journal of translational medicine · 2024Article
- Functional role of UNC13D in immune diseases and its therapeutic applications.Frontiers in immunology · 2024Review
- ER membrane contact sites support endosomal small GTPase conversion for exosome secretion.The Journal of cell biology · 2022Article
- Overlapping Machinery in Lysosome-Related Organelle Trafficking: A Lesson from Rare Multisystem Disorders.Cells · 2022Review
- Rab11 is required for lysosome exocytosis through the interaction with Rab3a, Sec15 and GRAB.Journal of cell science · 2021Article
- Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells.International journal of molecular sciences · 2021Article
- Regulation of protein homeostasis by unconventional protein secretion in mammalian cells.Seminars in cell & developmental biology · 2018Review
- Review
- Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment.Scientific reports · 2018Article
- Recycling endosomes in human cytotoxic T lymphocytes constitute an auxiliary intracellular trafficking pathway for newly synthesized perforin.Immunologic research · 2017Article
- Dynamic reorganization of the endomembrane system during spermatogenesis in Marchantia polymorpha.Journal of plant research · 2017Article
- Munc13-4 functions as a CaMolecular biology of the cell · 2017Article
- Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes.Cellular and molecular life sciences : CMLS · 2017Review
- mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways.Frontiers in cellular neuroscience · 2017Article
- Chediak-Higashi syndrome: Lysosomal trafficking regulator domains regulate exocytosis of lytic granules but not cytokine secretion by natural killer cells.The Journal of allergy and clinical immunology · 2016Article
- Interplay between Rab27a effectors in pancreatic β-cells.World journal of diabetes · 2015Review
- Molecular mechanisms regulating cytotoxic lymphocyte development and function, and their associations to human diseases.Frontiers in immunology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural Killer cells are a subset of cytotoxic lymphocytes that are important in host defense against infections and transformed cells. They exert this function through recognition of target cells by cell surface receptors, which triggers a signaling program that results in a re-orientation of the microtubule organizing center and secretory lysosomes toward the target cell. Upon movement of secretory lysosomes to the plasma membrane and subsequent fusion, toxic proteins are released by secretory lysosomes in the immunological synapse which then enter and kill the target cell. In this minireview we highlight recent progress in our knowledge of late steps in this specialized secretion pathway and address important open questions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.