ArticleFrontiers in human neuroscience2013
Early detection of microstructural white matter changes associated with arterial pulsatility.
Article in Frontiers in human neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Noninvasive Pulse Measurements for Cardiovascular Health Monitoring and Diagnoses.Advances in experimental medicine and biology · 2026Review
- A Lumped Parameter Modelling Study of Leukoaraiosis Suggests Its Vascular Pathophysiology May Be Similar to Normal-Pressure Hydrocephalus.Brain sciences · 2025Article
- Article
- Biological sex influences relationships between cerebral pulsatility and white matter hyperintensities in aging adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- Venous compression causes chronic cerebral ischaemia in normal pressure hydrocephalus patients.Fluids and barriers of the CNS · 2025Article
- Measuring pulsatile cortical blood flow and volume during carotid endarterectomy.Biomedical optics express · 2024Article
- Correlation between Carotid Blood Flow Velocity and Total Magnetic Resonance Imaging Burden of Cerebral Small Vessel Disease in Patients with Recent Small Subcortical Infarcts.Current neurovascular research · 2024Article
- Application of ultrasound technique to evaluate the testicular function and its correlation to the sperm quality after different collection frequency in rams.Frontiers in veterinary science · 2022Article
- Potential Diffusion Tensor Imaging Biomarkers for Elucidating Intra-Individual Age-Related Changes in Cognitive Control and Processing Speed.Frontiers in aging neuroscience · 2022Article
- A healthy mind in a healthy body: Effects of arteriosclerosis and other risk factors on cognitive aging and dementia.The psychology of learning and motivation · 2022Article
- Assessment of carotid stiffness by measuring carotid pulse wave velocity using a single-slice oblique-sagittal phase-contrast MRI.Magnetic resonance in medicine · 2021Article
- Cerebroarterial pulsatility and resistivity indices are associated with cognitive impairment and white matter hyperintensity in elderly subjects: A phase-contrast MRI study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Cerebral arterial pulsatility is associated with features of small vessel disease in patients with acute stroke and TIA: a 4D flow MRI study.Journal of neurology · 2020Article
- Distinct association between cerebral arterial pulsatility and subtypes of cerebral small vessel disease.PloS one · 2020Article
- Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Cognition in the First Year After a Minor Stroke, Transient Ischemic Attack, or Mimic Event and the Role of Vascular Risk Factors.Frontiers in neurology · 2020Article
- Cerebral Arterial Pulsatility and Global White Matter Microstructure Impact Spatial Working Memory in Older Adults With and Without Cardiovascular Risk Factors.Frontiers in aging neuroscience · 2020Article
- Ambulatory pulse pressure, brain neuronal fiber integrity, and cerebral blood flow in older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Impact of slow breathing on the blood pressure and subarachnoid space width oscillations in humans.Scientific reports · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased cerebral blood flow pulsatility is common in vascular dementia and is associated with macrostructural damage to cerebral white matter or leukoaraiosis (LA). In this study, we examine whether cerebral blood flow pulsatility is associated with macrostructural and microstructural changes in cerebral white matter in older adults with no or mild LA and no evidence of dementia. Diffusion Tensor Imaging was used to measure fractional anisotropy (FA), an index of the microstructural integrity of white matter, and radial diffusivity (RaD), a measure sensitive to the integrity of myelin. When controlling for age, increased arterial pulsation was associated with deterioration in both measures of white matter microstructure but not LA severity. A stepwise multiple linear regression model revealed that arterial pulsatility index was the strongest predictor of FA (R = 0.483, adjusted R (2) = 0.220), followed by LA severity, but not age. These findings suggest that arterial pulsatility may provide insight into age-related reduction in white matter FA. Specifically, increased arterial pulsatility may increase perivascular shear stress and lead to accumulation of damage to perivascular oligodendrocytes, resulting in microstructural changes in white matter and contributing to proliferation of LA over time. Changes in cerebral blood flow pulsatility may therefore provide a sensitive index of white matter health that could facilitate the early detection of risk for perivascular white matter damage and the assessment of the effectiveness of preventative treatment targeted at reducing pulsatility.
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