ArticleThe Journal of biological chemistry2014
Leptin signaling is required for leucine deprivation-enhanced energy expenditure.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Impacts of essential amino acids on energy balance.Molecular metabolism · 2022Review
- Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system.Journal of advanced research · 2021Article
- A fifty percent leucine-restricted diet reduces fat mass and improves glucose regulation.Nutrition & metabolism · 2021Article
- Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis.Nutrients · 2020Review
- Adipocyte-specific gp130 signalling mediates exercise-induced weight reduction.International journal of obesity (2005) · 2020Article
- Intermittent administration of a leucine-deprived diet is able to intervene in type 2 diabetes inHeliyon · 2018Article
- Gender-Associated Impact of Early Leucine Supplementation on Adult Predisposition to Obesity in Rats.Nutrients · 2018Article
- Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure.Open biology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptin signaling in the hypothalamus is crucial in energy homeostasis. We have previously shown that dietary deprivation of the essential amino acid leucine in mice stimulates fat loss by increasing energy expenditure. The involvement of leptin signaling in this regulation, however, has not been reported. Here, we show that leucine deprivation promotes leptin signaling in mice maintained on an otherwise normal diet and restores leptin responses in mice maintained on a high fat diet, a regimen known to induce leptin resistance. In addition, we found that leucine deprivation stimulated energy expenditure, and fat loss was largely blocked in db/db mice homozygous for a mutation in leptin receptor and a knock-in mouse line Y3F with abrogation of leptin receptor Tyr(1138)-mediated signal transducer and activator transcript 3 signaling. Overall, our studies describe a novel link between hypothalamic leptin signaling and stimulation of energy expenditure under leucine deprivation.
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