ArticleThe Journal of biological chemistry2014
Structural basis of biological NO generation by octaheme oxidoreductases.
Article in The Journal of biological chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 106 citations in OpenAlex.
- Photoholes within cyanobacterial mats can account for the origin of anammox bacteria and ancient nitrogen loss.Nature ecology & evolution · 2026Article
- Origin and Evolution of Key Enzymes in the Anammox Pathway Revisited.Genome biology and evolution · 2026Article
- Nitric oxide-forming nitrite reductases in the anaerobic ammonium oxidizer Kuenenia stuttgartiensis.FEBS open bio · 2025Article
- Cytochromes P460 and c'-β: exploiting a novel fold for multiple functions.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2025Review
- Acid tolerance and metabolic potential of comammox and nitrite-oxidizingISME communications · 2025Article
- Fractionating proteins with nitrite-reducing activity in "Frontiers in microbiology · 2025Article
- A survey of the Desulfuromonadia "cytochromome" provides a glimpse of the unexplored diversity of multiheme cytochromes in nature.BMC genomics · 2024Article
- Strategy to mitigate substrate inhibition in wastewater treatment systems.Nature communications · 2024Article
- Juglone, a plant-derived 1,4-naphthoquinone, binds to hydroxylamine oxidoreductase and inhibits the electron transfer to cytochromeApplied and environmental microbiology · 2023Article
- Outer coordination sphere influences on cofactor maturation and substrate oxidation by cytochrome P460.Chemical science · 2023Article
- Diversity of the Hydroxylamine Oxidoreductase (HAO) Gene and Its Enzyme Active Site in Agricultural Field Soils.Microbes and environments · 2023Article
- Nitric Oxide, Nitric Oxide Formers and Their Physiological Impacts in Bacteria.International journal of molecular sciences · 2022Review
- Hydrazines as Substrates and Inhibitors of the Archaeal Ammonia Oxidation Pathway.Applied and environmental microbiology · 2022Article
- Nature's nitrite-to-ammonia expressway, with no stop at dinitrogen.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022Review
- Dirammox Is Widely Distributed and Dependently Evolved inFrontiers in microbiology · 2022Article
- NHMicrobes and environments · 2022Article
- Specificity of SmallACS omega · 2021Article
- Heme P460: A (Cross) Link to Nitric Oxide.Accounts of chemical research · 2020Article
- Multiheme hydroxylamine oxidoreductases produce NO during ammonia oxidation in methanotrophs.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Biological and Bioinspired Inorganic N-N Bond-Forming Reactions.Chemical reviews · 2020Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Nitric oxide is an important molecule in all domains of life with significant biological functions in both pro- and eukaryotes. Anaerobic ammonium-oxidizing (anammox) bacteria that contribute substantially to the release of fixed nitrogen into the atmosphere use the oxidizing power of NO to activate inert ammonium into hydrazine (N2H4). Here, we describe an enzyme from the anammox bacterium Kuenenia stuttgartiensis that uses a novel pathway to make NO from hydroxylamine. This new enzyme is related to octaheme hydroxylamine oxidoreductase, a key protein in aerobic ammonium-oxidizing bacteria. By a multiphasic approach including the determination of the crystal structure of the K. stuttgartiensis enzyme at 1.8 Å resolution and refinement and reassessment of the hydroxylamine oxidoreductase structure from Nitrosomonas europaea, both in the presence and absence of their substrates, we propose a model for NO formation by the K. stuttgartiensis enzyme. Our results expand the understanding of the functions that the widespread family of octaheme proteins have.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.