ArticleeLife2013
ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetles.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 105 citations in OpenAlex.
- Aphid adaptation to plant secondary metabolites: adaptive mechanism of resistance evolution and future prospects.Horticulture research · 2026Article
- An integrative strategy used by the aphid Uroleucon formosanum to counter host sesquiterpene lactone defense: Insights from combined genomic and transcriptomic analysis.Insect science · 2025Article
- Chromosome-level genome assembly of the medicinal insect Blaps rhynchopetera using Nanopore and Hi-C technologies.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Substrate Specificity of ABCB Transporters Predicted by Docking Simulations Can Be Confirmed by Experimental Tests.Molecules (Basel, Switzerland) · 2024Article
- microRNA maintains nutrient homeostasis in the symbiont-host interaction.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Insecticide resistance reduces the profitability of insect-resistant rice cultivars.Journal of advanced research · 2024Article
- Girdling behavior of the longhorn beetle modulates the host plant to enhance larval performance.BMC ecology and evolution · 2024Article
- Article
- ABCH2 transporter mediates deltamethrin uptake and toxicity in the malaria vector Anopheles coluzzii.PLoS pathogens · 2023Article
- No-cost meals might not exist for insects feeding on toxic plants.Biology open · 2023Review
- Phenotypic screen and transcriptomics approach complement each other in functional genomics of defensive stink gland physiology.BMC genomics · 2022Article
- Rapid and Selective Absorption of Plant Defense Compounds From the Gut of a Sequestering Insect.Frontiers in physiology · 2022Article
- Functional and Structural Diversity of Insect Glutathione S-transferases in Xenobiotic Adaptation.International journal of biological sciences · 2022Review
- Metabolization and sequestration of plant specialized metabolites in insect herbivores: Current and emerging approaches.Frontiers in physiology · 2022Review
- Article
- Sugar transporters enable a leaf beetle to accumulate plant defense compounds.Nature communications · 2021Article
- The draft genome of the specialist flea beetle Altica viridicyanea (Coleoptera: Chrysomelidae).BMC genomics · 2021Article
- ABCB transporters in a leaf beetle respond to sequestered plant toxins.Proceedings. Biological sciences · 2020Article
- The ABCB Multidrug Resistance Proteins Do Not Contribute to Ivermectin Detoxification in the Colorado Potato Beetle,Insects · 2020Article
- Insect ATP-Binding Cassette (ABC) Transporters: Roles in Xenobiotic Detoxification and Bt Insecticidal Activity.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant-herbivore interactions dominate the planet's terrestrial ecology. When it comes to host-plant specialization, insects are among the most versatile evolutionary innovators, able to disarm multiple chemical plant defenses. Sequestration is a widespread strategy to detoxify noxious metabolites, frequently for the insect's own benefit against predation. In this study, we describe the broad-spectrum ATP-binding cassette transporter CpMRP of the poplar leaf beetle, Chrysomela populi as the first candidate involved in the sequestration of phytochemicals in insects. CpMRP acts in the defensive glands of the larvae as a pacemaker for the irreversible shuttling of pre-selected metabolites from the hemolymph into defensive secretions. Silencing CpMRP in vivo creates a defenseless phenotype, indicating its role in the secretion process is crucial. In the defensive glands of related leaf beetle species, we identified sequences similar to CpMRP and assume therefore that exocrine gland-based defensive strategies, evolved by these insects to repel their enemies, rely on ABC transporters as a key element. DOI: http://dx.doi.org/10.7554/eLife.01096.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.