ArticleLab on a chip2014
Submillisecond mixing in a continuous-flow, microfluidic mixer utilizing mid-infrared hyperspectral imaging detection.
Article in Lab on a chip, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Surface plasmons-phonons for mid-infrared hyperspectral imaging.Science advances · 2024Article
- Amplified piezoelectrically actuated on-chip flow switching for a rapid and stable microfluidic fluorescence activated cell sorter.RSC advances · 2020Article
- An integrated, optofluidic system with aligned optical waveguides, microlenses, and coupling prisms for fluorescence sensing.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2020Article
- Anodic bonding of mid-infrared transparent germanate glasses for high pressure - high temperature microfluidic applications.Science and technology of advanced materials · 2020Article
- Infrared Spectroscopic Imaging Advances as an Analytical Technology for Biomedical Sciences.Analytical chemistry · 2018Review
- Sandwich-format 3D printed microfluidic mixers: a flexible platform for multi-probe analysis.Journal of micromechanics and microengineering : structures, devices, and systems · 2015Article
- Wide-field FTIR microscopy using mid-IR pulse shaping.Optics express · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We report a continuous-flow, microfluidic mixer utilizing mid-infrared hyperspectral imaging detection, with an experimentally determined, submillisecond mixing time. The simple and robust mixer design has the microfluidic channels cut through a polymer spacer that is sandwiched between two IR transparent windows. The mixer hydrodynamically focuses the sample stream with two side flow channels, squeezing it into a thin jet and initiating mixing through diffusion and advection. The detection system generates a mid-infrared hyperspectral absorbance image of the microfluidic sample stream. Calibration of the hyperspectral image yields the mid-IR absorbance spectrum of the sample versus time. A mixing time of 269 μs was measured for a pD jump from 3.2 to above 4.5 in a D2O sample solution of adenosine monophosphate (AMP), which acts as an infrared pD indicator. The mixer was further characterized by comparing experimental results with a simulation of the mixing of an H2O sample stream with a D2O sheath flow, showing good agreement between the two. The IR microfluidic mixer eliminates the need for fluorescence labeling of proteins with bulky, interfering dyes, because it uses the intrinsic IR absorbance of the molecules of interest, and the structural specificity of IR spectroscopy to follow specific chemical changes such as the protonation state of AMP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.