ArticleJournal of cell communication and signaling2014
Ca(2+)/H (+) exchange, lumenal Ca(2+) release and Ca (2+)/ATP coupling ratios in the sarcoplasmic reticulum ATPase.
Article in Journal of cell communication and signaling, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 52 citations in OpenAlex.
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- Inducible skeletal muscle-specific p53 deletion alleviates high-fat diet-induced insulin resistance by modulating mitochondria-associated membrane in obese mice.Redox biology · 2025Article
- The contribution of the Golgi and the endoplasmic reticulum to calcium and pH homeostasis in Toxoplasma gondii.The Journal of biological chemistry · 2025Article
- Plastic recognition and electrogenic uniport translocation of 1Chemical science · 2023Article
- Role of calcium-sensor proteins in cell membrane repair.Bioscience reports · 2023Review
- Sarcoplasmic Reticulum from Horse Gluteal Muscle Is Poised for Enhanced Calcium Transport.Veterinary sciences · 2021Article
- Structural Basis for the Function of the C-Terminal Proton Release Pathway in the Calcium Pump.International journal of molecular sciences · 2021Article
- Transmembrane Cu(I) P-type ATPase pumps are electrogenic uniporters.Dalton transactions (Cambridge, England : 2003) · 2020Article
- Protein Adsorption on Solid Supported Membranes: Monitoring the Transport Activity of P-Type ATPases.Molecules (Basel, Switzerland) · 2020Review
- Multiscale Simulation Reveals Passive Proton Transport Through SERCA on the Microsecond Timescale.Biophysical journal · 2020Article
- Regulation of ion transport from within ion transit pathways.The Journal of general physiology · 2020Review
- Enhanced cellulase production by decreasing intercellular pH through HBiotechnology for biofuels · 2019Article
- Endolysosomal CaCancers · 2018Review
- No voltage change at skeletal muscle SR membrane during CaThe Journal of general physiology · 2018Article
- Sarcolipin Makes Heat, but Is It Adaptive Thermogenesis?Frontiers in physiology · 2018Article
- Drug Interactions With the CaFrontiers in molecular biosciences · 2018Review
- SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo.Scientific reports · 2017Article
- The CaMolecular bioSystems · 2017Review
- Conformational Transitions and Alternating-Access Mechanism in the Sarcoplasmic Reticulum Calcium Pump.Journal of molecular biology · 2017Article
- Muscle Non-shivering Thermogenesis and Its Role in the Evolution of Endothermy.Frontiers in physiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ca(2+) transport ATPase (SERCA) of sarcoplasmic reticulum (SR) plays an important role in muscle cytosolic signaling, as it stores Ca(2+) in intracellular membrane bound compartments, thereby lowering cytosolic Ca(2+) to induce relaxation. The stored Ca(2+) is in turn released upon membrane excitation to trigger muscle contraction. SERCA is activated by high affinity binding of cytosolic Ca(2+), whereupon ATP is utilized by formation of a phosphoenzyme intermediate, which undergoes protein conformational transitions yielding reduced affinity and vectorial translocation of bound Ca(2+). We review here biochemical and biophysical evidence demonstrating that release of bound Ca(2+) into the lumen of SR requires Ca(2+)/H(+) exchange at the low affinity Ca(2+) sites. Rise of lumenal Ca(2+) above its dissociation constant from low affinity sites, or reduction of the H(+) concentration by high pH, prevent Ca(2+)/H(+) exchange. Under these conditions Ca(2+) release into the lumen of SR is bypassed, and hydrolytic cleavage of phosphoenzyme may yield uncoupled ATPase cycles. We clarify how such Ca(2+)pump slippage does not occur within the time length of muscle twitches, but under special conditions and in special cells may contribute to thermogenesis.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.