ArticleNaunyn-Schmiedeberg's archives of pharmacology1986
Different effects of noradrenaline, angiotensin II and BAY K 8644 on the abolition of autoregulation of renal blood flow by verapamil.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Renal autoregulation and blood pressure management in circulatory shock.Critical care (London, England) · 2018Review
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Autoregulation of renal blood flow in the conscious dog and the contribution of the tubuloglomerular feedback.The Journal of physiology · 1998Article
- Differential antagonism by Bay K 8644 of vasodilator effects of nifedipine, diltiazem, nicorandil and nitroglycerin in dog femoral circulation.British journal of pharmacology · 1988Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the role of Ca channels in autoregulation of renal blood flow in response to changes of perfusion pressure, experiments were performed with perfused kidney in anesthetized dogs using a Ca channel activator, BAY K 8644, and vasoconstrictors such as noradrenaline and angiotensin II. Control observations usually showed excellent autoregulation of renal blood flow at pressures between 120 and 200 mm Hg, the autoregulatory index being less than 0.2. Verapamil (50 micrograms/min, i.a. infusion) obviously inhibited the renal autoregulation. Simultaneous infusion of 5 micrograms/min of BAY K 8644 with verapamil prevented both the increase of renal blood flow and the impairment of the autoregulation caused by verapamil. Whereas simultaneous infusion of noradrenaline (1 and 3 micrograms/min) or angiotensin II (0.1 and 0.3 micrograms/min) with verapamil dose-dependently reduced renal blood flow, these drugs could not antagonize the inhibitory effect of verapamil on autoregulation. The present experiments show that Ca channels play an important role in establishing renal autoregulation, and that a mere vasoconstriction by noradrenaline and angiotensin II is distinguished from autoregulatory performance.
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Registered trials
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