Evidence map›Paper›PMID 24301647›Full record

ReviewTranslational psychiatry2013

Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes.

A P Mullin, A Gokhale, A Moreno-De-Luca, S Sanyal, J L Waddington, V Faundez

Abstract readReview
In one paragraph

Review in Translational psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed.

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  19. Subjective sleep assessment in individuals withJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  20. Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A P MullinDepartment of Cell Biology, Emory University School of Medicine, Center for Social Translational Neuroscience, Emory University, Atlanta, GA, USA.
A Gokhale
A Moreno-De-Luca
S Sanyal
J L Waddington
V Faundez

Funding

TRAINING IN SYSTEMS AND INTEGRATIVE BIOLOGY:NEUROSCIENCET32GM008605 · NIGMS · EMORY UNIVERSITY · PI SMITH, YOLAND · 1996 to 2015
$4.2M
Cellular Mechanisms of Neuronal Metal Transport and ToxicityR01GM077569 · NIGMS · EMORY UNIVERSITY · PI FAUNDEZ, VICTOR · 2006 to 2016
$2.6M
Mechanisms of Endosome Trafficking in NeuronsR01NS042599 · NINDS · EMORY UNIVERSITY · PI FAUNDEZ, VICTOR · 2003 to 2012
$2.5M
Mechanisms of Endosome Trafficking in NeuronsR56NS042599 · NINDS · EMORY UNIVERSITY · PI FAUNDEZ, VICTOR · 2008 to 2008
$339k
NIGMS NIH HHS GM077569NIGMS NIH HHS R01 GM077569NIGMS NIH HHS T32 GM008605NINDS NIH HHS NS42599NINDS NIH HHS R01 NS042599NINDS NIH HHS R56 NS042599
6 · The paper itself

Abstract

Neurodevelopmental disorders such as intellectual disability, autism spectrum disorder and schizophrenia lack precise boundaries in their clinical definitions, epidemiology, genetics and protein-protein interactomes. This calls into question the appropriateness of current categorical disease concepts. Recently, there has been a rising tide to reformulate neurodevelopmental nosological entities from biology upward. To facilitate this developing trend, we propose that identification of unique proteomic signatures that can be strongly associated with patient's risk alleles and proteome-interactome-guided exploration of patient genomes could define biological mechanisms necessary to reformulate disorder definitions.

Indexed as

Child Development Disorders, PervasiveDevelopmental DisabilitiesGenomeHumansIntellectual DisabilityProteomeSchizophreniaProteome

Identifiers

PMID24301647
PMCPMC4030327

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.