ReviewDevelopment (Cambridge, England)2013
Mechanisms of scaling in pattern formation.
Review in Development (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed.
- Embryonic scaling: morphogen gradients, size sensing, and scaler genes.Frontiers in cell and developmental biology · 2026Review
- Static morphogen scaling enables proportional growth in a tissue growth model inspired by axolotl limb regeneration.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Intrinsically robust and scalable biofilm segmentation under diverse physical growth conditions.iScience · 2024Article
- Early autonomous patterning of the anteroposterior axis in gastruloids.Development (Cambridge, England) · 2024Article
- Dynamics of morphogen source formation in a growing tissue.PLoS computational biology · 2024Article
- Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain.iScience · 2023Article
- Article
- A group theoretic approach to model comparison with simplicial representations.Journal of mathematical biology · 2022Article
- Patterning principles of morphogen gradients.Open biology · 2022Review
- Temporal scaling inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Archetypal Architecture Construction, Patterning, and Scaling Invariance in a 3D Embryoid Body Differentiation Model.Frontiers in cell and developmental biology · 2022Article
- Scaling of internal organs during Drosophila embryonic development.Biophysical journal · 2021Article
- Signaling gradients in surface dynamics as basis for planarian regeneration.Journal of mathematical biology · 2021Article
- Diversity and robustness of bone morphogenetic protein pattern formation.Development (Cambridge, England) · 2021Review
- Molecular and Mechanical Cues for Somite Periodicity.Frontiers in cell and developmental biology · 2021Review
- Integrating cellular dimensions with cell differentiation during early development.Current opinion in cell biology · 2020Review
- Scaling a Dpp Morphogen Gradient through Feedback Control of Receptors and Co-receptors.Developmental cell · 2020Article
- Pattern formation mechanisms of self-organizing reaction-diffusion systems.Developmental biology · 2020Review
- Interplay between morphogen-directed positional information systems and physiological signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Integrated K+ channel and K+Cl- cotransporter functions are required for the coordination of size and proportion during development.Developmental biology · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Many organisms and their constituent tissues and organs vary substantially in size but differ little in morphology; they appear to be scaled versions of a common template or pattern. Such scaling involves adjusting the intrinsic scale of spatial patterns of gene expression that are set up during development to the size of the system. Identifying the mechanisms that regulate scaling of patterns at the tissue, organ and organism level during development is a longstanding challenge in biology, but recent molecular-level data and mathematical modeling have shed light on scaling mechanisms in several systems, including Drosophila and Xenopus. Here, we investigate the underlying principles needed for understanding the mechanisms that can produce scale invariance in spatial pattern formation and discuss examples of systems that scale during development.
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