ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2014
Bone marrow-derived endothelial progenitor cells protect postischemic axons after traumatic brain injury.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Autologous bone marrow mononuclear cell administration for neurological sequelae after traumatic brain injury: a matched control study.Brain communications · 2025Trial
- Potential effect of endothelial progenitor cells on pentylenetetrazole-induced seizures in rats: an evaluation of relevant lncRNAs.Journal of Zhejiang University. Science. B · 2025Article
- Endothelial Progenitor Cells: A Brief Update.International journal of stem cells · 2024Review
- Combination human umbilical cord perivascular and endothelial colony forming cell therapy for ischemic cardiac injury.NPJ Regenerative medicine · 2023Article
- Blood-Derived Progenitor Cells Are Depleted in Older Adults with Cognitive Impairment: A Role for Vascular Resilience?Journal of Alzheimer's disease : JAD · 2023Article
- Fibrinogen Interaction with Astrocyte ICAM-1 and PrPInternational journal of molecular sciences · 2021Article
- Conditioned medium-preconditioned EPCs enhanced the ability in oligovascular repair in cerebral ischemia neonatal rats.Stem cell research & therapy · 2021Article
- Secretion of proteins and antibody fragments from transiently transfected endothelial progenitor cells.Journal of cellular and molecular medicine · 2020Article
- Autologous bone marrow mononuclear cell transplantation in patients with chronic traumatic brain injury- a clinical study.Cell regeneration (London, England) · 2020Article
- miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration.Molecular medicine reports · 2020Article
- Effect of Low Intensity Transcranial Ultrasound (LITUS) on Post-traumatic Brain Edema in Rats: Evaluation by Isotropic 3-Dimensional T2 and Multi-TE T2 Weighted MRI.Frontiers in neurology · 2020Article
- Therapeutic potential of endothelial progenitor cells in a rat model of epilepsy: Role of autophagy.Journal of advanced research · 2019Article
- Endothelial Progenitor Cells Conditioned Medium Supports Number of GABAergic Neurons and Exerts Neuroprotection in Cultured Striatal Neuronal Progenitor Cells.Cell transplantation · 2019Article
- Advance of Stem Cell Treatment for Traumatic Brain Injury.Frontiers in cellular neuroscience · 2019Review
- Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion.Stroke · 2018Article
- High-mobility group box 1 facilitates migration of neural stem cells via receptor for advanced glycation end products signaling pathway.Scientific reports · 2018Article
- Age-related Impairment of Vascular Structure and Functions.Aging and disease · 2017Review
- Rehabilitation Treatment and Progress of Traumatic Brain Injury Dysfunction.Neural plasticity · 2017Review
- Therapeutic Prospective of Infused Allogenic Cultured Mesenchymal Stem Cells in Traumatic Brain Injury Mice: A Longitudinal Proton Magnetic Resonance Spectroscopy Assessment.Stem cells translational medicine · 2017Article
- Poly-L-ornithine enhances migration of neural stem/progenitor cells via promoting α-Actinin 4 binding to actin filaments.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter sparing after traumatic brain injury (TBI) is an important predictor of survival and outcome. Blood vessels and axons are intimately associated anatomically and developmentally. Neural input is required for appropriate vascular patterning, and vascular signaling is important for neuron development and axon growth. Owing to this codependence between endothelial cells and axons during development and the contribution of endothelial progenitor cells (EPCs) in ischemic injury, we hypothesized that EPCs are important in axonal survival after TBI. We examined the effects of allogenic-cultured EPCs on white matter protection and microvascular maintenance after midline fluid percussion injury in adult Sprague-Dawley rats. We used two in vitro models of injury, mechanical stretch and oxygen-glucose deprivation (OGD), to examine the effects of EPCs on the mechanical and ischemic components of brain trauma, respectively. Our results indicate that EPCs improve the white matter integrity and decrease capillary breakdown after injury. Cultured cortical neurons exposed to OGD had less axon degeneration when treated with EPC-conditioned media, whereas no effect was seen in axons injured by mechanical stretch. The results indicate that EPCs are important for the protection of the white matter after trauma and represent a potential avenue for therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.