ArticleInternational journal of obesity (2005)2014
Association of leptin and insulin with childhood obesity and retinal vessel diameters.
Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Unhealthy Lifestyles and Retinal Vessel Calibers among Children and Adolescents: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Retinal vascular imaging in early life: insights into processes and risk of cardiovascular disease.The Journal of physiology · 2016Pooled it
- Retinal Microvascular Calibres and Body Fat Indices in Young Adults.International journal of environmental research and public health · 2026Article
- The influence of insulin on diabetic retinopathy and retinal vessel parameters in diabetes.Diabetology & metabolic syndrome · 2024Article
- Obesity-induced ocular changes in children and adolescents: A review.Frontiers in pediatrics · 2023Review
- Vascular biomarkers in the prevention of childhood cardiovascular risk: From concept to clinical implementation.Frontiers in cardiovascular medicine · 2022Review
- Review
- Inflammation mediates the relationship between obesity and retinal vascular calibre in 11-12 year-olds children and mid-life adults.Scientific reports · 2020Article
- Effect of weight loss on the retinochoroidal structural alterations among patients with exogenous obesity.PloS one · 2020Article
- Characteristics of the retinal microvasculature in association with cardiovascular risk markers in children with overweight, obesity and morbid obesity.Scientific reports · 2018Article
- Assessing Microvascular Function in Humans from a Chronic Disease Perspective.Journal of the American Society of Nephrology : JASN · 2017Review
- Insulin Sensitivity and Inflammation Mediate the Impact of Fitness on Cerebrovascular Health in Adolescents.Childhood obesity (Print) · 2017Article
- Body fat evolution as predictor of retinal microvasculature in children.International journal of obesity (2005) · 2017Article
- Does Physical Fitness Buffer the Relationship between Psychosocial Stress, Retinal Vessel Diameters, and Blood Pressure among Primary Schoolchildren?BioMed research international · 2016Article
- Retinal vessel alterations and cerebral white matter microstructural damage in obese adolescents with metabolic syndrome.JAMA pediatrics · 2014Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveChildhood obesity is associated with an impaired retinal microcirculation. The aim of the study was to investigate the association between specific obesity-related biomarkers, physical fitness and retinal vessel diameters in school children. DESIGN AND SUBJECTS: We studied 381 children aged 10-11 years (body mass index (BMI): 19.3±3.7 kg m(-2)) in a school-based setting. MEASUREMENTS: Anthropometric measurements and blood sampling were conducted using standard protocols for children. The serum biomarkers leptin, adiponectin, insulin as well as interleukin-6 (IL-6) were analyzed. Physical fitness was determined by a six-item-test battery and physical activity by use of a questionnaire. Central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) and the arteriolar-to-venular diameter ratio (AVR) were assessed with a non-mydriatic vessel analyzer (SVA-T) using a computer-based program.
resultsCompared with normal weight children (n=254), obese children (n=39) showed higher leptin (P<0.001), higher insulin (P<0.001), higher IL-6 (P<0.001) and lower adiponectin levels (P=0.013). Obese children demonstrated wider CRVE (P=0.041) and lower AVR (P<0.001). Higher leptin levels were associated with wider CRVE (P=0.032) and lower AVR (P=0.010), that was BMI dependent. Insulin levels were associated with arteriolar (P=0.045) and venular dilatation (P=0.034) after adjustment for BMI. No significant associations between adiponectin levels, IL-6 levels, physical fitness or physical activity and retinal vessel diameter were observed. Lower leptin levels were independently correlated with higher physical fitness (r=-0.33; P<0.001).
conclusionLeptin and insulin levels are associated with changes of the retinal microcirculation. Especially insulin seems to be a good target marker for the cardiometabolic risk assessment in children since elevated insulin levels are independently associated with microvascular end-organ alterations at an early stage. Lifestyle intervention studies are warranted to examine whether improvement of physical fitness or weight reduction can affect cardiometabolic risk markers and reverse alterations of the retinal microcirculation.
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