ArticleJournal of visualized experiments : JoVE2013
Handwriting analysis indicates spontaneous dyskinesias in neuroleptic naïve adolescents at high risk for psychosis.
Article in Journal of visualized experiments : JoVE, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- [Antipsychotic-induced motor symptoms in schizophrenic psychoses-Part 3 : Tardive dyskinesia].Der Nervenarzt · 2019Pooled it
- Speech as an objective measure of psychomotor dysfunction in major depressive disorder: validation from non-speech motor measures.Psychiatry research · 2026Article
- Capturing Motor Signs in Psychosis: How the New Technologies Can Improve Assessment and Treatment?Schizophrenia bulletin · 2025Article
- Imitative inhibitory control is associated with psychotic experiences in a sample from the general population.Frontiers in psychiatry · 2024Article
- Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Comparing a Computerized Digit Symbol Test to a Pen-and-Paper Classic.Schizophrenia bulletin open · 2023Article
- Movement markers of schizophrenia: a detailed analysis of patients' gait patterns.European archives of psychiatry and clinical neuroscience · 2022Article
- Neural mechanisms of motor dysfunction in individuals at clinical high-risk for psychosis: Evidence for impairments in motor activation.Journal of psychopathology and clinical science · 2022Article
- Handwriting Kinematics in Patients with Schizophrenia Treated with Long-Acting Injectable Atypical Antipsychotics: Results From the ALPINE Study.Schizophrenia bulletin open · 2022Article
- The Use of Handwriting Changes for the Follow-up of Patients with Bipolar Disorder.Noro psikiyatri arsivi · 2022Article
- Examining Motor Anticipation in Handwriting as an Indicator of Motor Dysfunction in Schizophrenia.Frontiers in psychology · 2022Article
- The psychosis human connectome project: An overview.NeuroImage · 2021Article
- Longitudinal Assessment and Functional Neuroimaging of Movement Variability Reveal Novel Insights Into Motor Dysfunction in Clinical High Risk for Psychosis.Schizophrenia bulletin · 2020Article
- Observational
- An Examination of Psychomotor Disturbance in Current and Remitted MDD: An RDoC Study.Journal of psychiatry and brain science · 2020Article
- Exploring the Relationship of Transdiagnostic Mood and Psychosis Symptom Domains with Motor Dysfunction.Neuropsychobiology · 2020Article
- Instrument-based assessment of motor function yields no evidence of dyskinesia in adult first-degree biological relatives of individuals with schizophrenia and schizoaffective disorder.Psychiatry research · 2019Article
- Handwriting movements for assessment of motor symptoms in schizophrenia spectrum disorders and bipolar disorder.PloS one · 2019Article
- Motion energy analysis reveals altered body movement in youth at risk for psychosis.Schizophrenia research · 2018Article
- Motor System Pathology in Psychosis.Current psychiatry reports · 2017Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Growing evidence suggests that movement abnormalities are a core feature of psychosis. One marker of movement abnormality, dyskinesia, is a result of impaired neuromodulation of dopamine in fronto-striatal pathways. The traditional methods for identifying movement abnormalities include observer-based reports and force stability gauges. The drawbacks of these methods are long training times for raters, experimenter bias, large site differences in instrumental apparatus, and suboptimal reliability. Taking these drawbacks into account has guided the development of better standardized and more efficient procedures to examine movement abnormalities through handwriting analysis software and tablet. Individuals at risk for psychosis showed significantly more dysfluent pen movements (a proximal measure for dyskinesia) in a handwriting task. Handwriting kinematics offers a great advance over previous methods of assessing dyskinesia, which could clearly be beneficial for understanding the etiology of psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.