Evidence map›Paper›PMID 24300584›Full record

ArticleThrombosis research2014

Risk factors for inpatient venous thromboembolism despite thromboprophylaxis.

Tzu-Fei Wang, Catherine A Wong, Paul E Milligan, Mark S Thoelke, Keith F Woeltje, Brian F Gage

Abstract read
In one paragraph

Article in Thrombosis research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Review
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  8. Article
  9. Acute Venous Thromboembolism Risk Highest Within 60 Days After Discharge From the Hospital in Patients With Inflammatory Bowel Diseases.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tzu-Fei WangWashington University School of Medicine, Saint Louis, MO, USA; Division of Hematology, Department of Medicine, The Ohio State University, OH, USA.
Catherine A WongCenter for Clinical Excellence, BJC HealthCare, Saint Louis, MO, USA.
Paul E MilliganWashington University School of Medicine, Saint Louis, MO, USA; Center for Clinical Excellence, BJC HealthCare, Saint Louis, MO, USA.
Mark S ThoelkeWashington University School of Medicine, Saint Louis, MO, USA.
Keith F WoeltjeWashington University School of Medicine, Saint Louis, MO, USA; Center for Clinical Excellence, BJC HealthCare, Saint Louis, MO, USA.
Brian F GageWashington University School of Medicine, Saint Louis, MO, USA. Electronic address: bgage@im.wustl.edu.

Funding

Translational Research Skills Development CoreU54HL112303 · NHLBI · WASHINGTON UNIVERSITY · PI SADLER, J EVAN · 2012 to 2016
$8.8M
GENETICS-InFORMATICS TRIAL (GIFT) OF WARFARIN TO PREVENT DVTR01HL097036 · NHLBI · WASHINGTON UNIVERSITY · PI GAGE, BRIAN F · 2009 to 2015
$5.0M
NHLBI NIH HHS R01 HL097036NHLBI NIH HHS U54 HL112303
6 · The paper itself

Abstract

introductionVenous thromboembolism (VTE) is the most common preventable cause of morbidity and mortality in the hospital. Adequate thromboprophylaxis has reduced the rate of hospital-acquired VTE substantially; however, some inpatients still develop VTE even when they are prescribed thromboprophylaxis. Predictors associated with thromboprophylaxis failure are unclear. In this study, we aimed to identify risk factors for inpatient VTE despite thromboprophylaxis. MATERIALS AND

methodsWe conducted a case-control study to identify independent predictors for inpatient VTE. Among patients discharged from the BJC HealthCare system between January 2010 and May 2011, we matched 94 cases who developed in-hospital VTE while taking thromboprophylaxis to 272 controls who did not develop VTE. Matching was done by hospital, patient age, month and year of discharge. We used multivariate conditional logistic regression to develop a VTE prediction model.

resultsWe identified five independent risk factors for in-hospital VTE despite thromboprophylaxis: hospitalization for cranial surgery, intensive care unit admission, admission leukocyte count >13,000/mm(3), presence of an indwelling central venous catheter, and admission from a long-term care facility.

conclusionsWe identified five risk factors associated with the development of VTE despite thromboprophylaxis in the hospital setting. By recognizing these high-risk patients, clinicians can prescribe aggressive VTE prophylaxis judiciously and remain vigilant for signs or symptoms of VTE.

Indexed as

AnticoagulantsCase-Control StudiesFemaleHumansLong-Term CareMaleMiddle AgedPostoperative ComplicationsRisk FactorsVenous ThromboembolismAnticoagulantsAgency for Healthcare Research and Quality Patient Safety Indicators 12, version 4.2AHRQ PSI 12Anticoagulationcentral venous catheterCIconfidence intervalCVCdeep vein thrombosisDVTICUINRintensive care unitinternational normalized ratioMEDENOX trialodds ratioORPE“prophylaxis in medical patients with enoxaparin” trialpulmonary embolismRisk factorsThromboprophylaxisvenous thromboembolismVenous thromboembolismVTE

Identifiers

PMID24300584
PMCPMC4469358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.