ArticlePharmaceutics2013
Physical and oxidative stability of uncoated and chitosan-coated liposomes containing grape seed extract.
Article in Pharmaceutics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 86 citations in OpenAlex.
- Development and Characterization of Liposome-Based Dermocosmetic Formulations with Red Grape Pomace andAntioxidants (Basel, Switzerland) · 2025Article
- Liposomes as Carriers of Bioactive Compounds in Human Nutrition.Foods (Basel, Switzerland) · 2024Review
- Extracellular vesicles derived from mesenchymal stem cells: the wine in Hebe's hands to treat skin aging.Precision clinical medicine · 2024Review
- Preparation of PhosphorylatedFoods (Basel, Switzerland) · 2024Article
- Design and advanced characterization of quercetin-loaded nano-liposomes prepared by high-pressure homogenization.Food chemistry · 2023Article
- Wild-Grown RomanianPlants (Basel, Switzerland) · 2023Article
- Rosehip Extract-Loaded Liposomes for Potential Skin Application: Physicochemical Properties of Non- and UV-Irradiated Liposomes.Plants (Basel, Switzerland) · 2023Article
- A nano-Liposomal formulation potentiates antioxidant, anti-inflammatory, and fibrinolytic activities of Allolobophora caliginosa coelomic fluid: formulation and characterization.BMC biotechnology · 2023Article
- Coating Materials to Increase the Stability of Liposomes.Polymers · 2023Review
- Preparation, physical properties, and evaluation of antioxidant capacity of aqueous grape extract loaded in chitosan-TPP nanoparticles.Food science & nutrition · 2022Article
- Application of engineered extracellular vesicles for targeted tumor therapy.Journal of biomedical science · 2022Review
- Extracellular vesicle: A magic lamp to treat skin aging, refractory wound, and pigmented dermatosis?Frontiers in bioengineering and biotechnology · 2022Review
- The Role of Ultrasound in the Preparation of Zein Nanoparticles/Flaxseed Gum Complexes for the Stabilization of Pickering Emulsion.Foods (Basel, Switzerland) · 2021Article
- Extracellular Vesicles-Based Drug Delivery Systems: A New Challenge and the Exemplum of Malignant Pleural Mesothelioma.International journal of molecular sciences · 2020Review
- Nanosystems for the Encapsulation of Natural Products: The Case of Chitosan Biopolymer as a Matrix.Pharmaceutics · 2020Review
- Characterization of nanoemulsion ofFood science & nutrition · 2020Article
- Techno-biofunctionality of mangostin extract-loaded virgin coconut oil nanoemulsion and nanoemulgel.PloS one · 2020Article
- Polyphenolic Extract fromNanomaterials (Basel, Switzerland) · 2019Article
- Effects of chitosan edible coating containing grape seed extract on the shelf-life of refrigerated rainbow trout fillet.Veterinary research forum : an international quarterly journal · 2018Article
- Liposomal Incorporation to Improve Dissolution and Stability of Rosmarinic Acid and Carvacrol Extracted from Oregano (BioMed research international · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyphenol-rich grape seed extract (0.1 w/w%) was incorporated in liposomes (1 w/w% soy lecithin) by high pressure homogenization (22,500 psi) and coated with chitosan (0.1 w/w%). Primary liposomes and chitosan-coated secondary liposomes containing grape seed extract showed good physical stability during 98 days of storage. Most of the polyphenols were incorporated in the shell of the liposomes (85.4%), whereas only 7.6% of the polyphenols of grape seed extract were located in the interior of the liposomes. Coating with chitosan did not change the polyphenol content in the liposomes (86.6%). The uncoated liposomes without grape seed extract were highly prone to lipid oxidation. The cationic chitosan coating, however, improved the oxidative stability to some extent, due to its ability to repel pro-oxidant metals. Encapsulated grape seed extract showed high antioxidant activity in both primary and secondary liposomes, which may be attributed to its polyphenol content. In conclusion, the best chemical stability of liposomes can be achieved using a combination of grape seed extract and chitosan.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.