ArticleEvolution; international journal of organic evolution2013
Shifting fitness landscapes in response to altered environments.
Article in Evolution; international journal of organic evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 131 citations in OpenAlex.
- Synthetic Approaches as Empirical Tools for Testing Evolutionary Theory.Genome biology and evolution · 2026Review
- Historical contingency limits adaptive diversification in a spatially structured environment.Evolution letters · 2026Article
- Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation.Molecular biology of the cell · 2025Article
- Fisher's Geometric Model as a Tool to Study Speciation.Cold Spring Harbor perspectives in biology · 2024Review
- Dominant negative mutations in yeast Hsp90 reveal triage decision mechanism targeting client proteins for degradation.bioRxiv : the preprint server for biology · 2024Article
- Competition-driven eco-evolutionary feedback reshapes bacteriophage lambda's fitness landscape and enables speciation.Nature communications · 2024Article
- Convergent genetic adaptation ofFrontiers in molecular biosciences · 2024Article
- Hypermutator emergence in experimentalEvolution letters · 2023Article
- A complete allosteric map of a GTPase switch in its native cellular network.Cell systems · 2023Article
- The ensemble of gene regulatory networks at mutation-selection balance.Journal of the Royal Society, Interface · 2023Article
- Integrating deep mutational scanning and low-throughput mutagenesis data to predict the impact of amino acid variants.GigaScience · 2022Article
- The Role of the Environment in Horizontal Gene Transfer.Molecular biology and evolution · 2022Article
- Overdominant and partially dominant mutations drive clonal adaptation in diploid Saccharomyces cerevisiae.Genetics · 2022Article
- Fluctuating Environments Maintain Genetic Diversity through Neutral Fitness Effects and Balancing Selection.Molecular biology and evolution · 2021Article
- Consequences of mutation accumulation for growth performance are more likely to be resource-dependent at higher temperatures.BMC ecology and evolution · 2021Article
- The Adaptive Potential of the Middle Domain of Yeast Hsp90.Molecular biology and evolution · 2021Article
- Bridging Tumorigenesis and Therapy Resistance With a Non-Darwinian and Non-Lamarckian Mechanism of Adaptive Evolution.Frontiers in oncology · 2021Article
- A two-step PCR assembly for construction of gene variants across large mutational distances.Biology methods & protocols · 2021Article
- Extreme Antagonism Arising from Gene-Environment Interactions.Biophysical journal · 2020Article
- Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
The role of adaptation in molecular evolution has been contentious for decades. Here, we shed light on the adaptive potential in Saccharomyces cerevisiae by presenting systematic fitness measurements for all possible point mutations in a region of Hsp90 under four environmental conditions. Under elevated salinity, we observe numerous beneficial mutations with growth advantages up to 7% relative to the wild type. All of these beneficial mutations were observed to be associated with high costs of adaptation. We thus demonstrate that an essential protein can harbor adaptive potential upon an environmental challenge, and report a remarkable fit of the data to a version of Fisher's geometric model that focuses on the fitness trade-offs between mutations in different environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.