ArticleScandinavian journal of primary health care2013
Long-term follow-up of patients with elevated serum calcium concentrations in Swedish primary care.
Article in Scandinavian journal of primary health care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Plasma albumin and calcium concentrations, and long-term mortality in primary health care patients in Sweden.Scandinavian journal of primary health care · 2020Article
- Bone mineral density in primary care patients related to serum calcium concentrations: a longitudinal cohort study from Sweden.Scandinavian journal of primary health care · 2018Article
- Italian Society of Endocrinology Consensus Statement: definition, evaluation and management of patients with mild primary hyperparathyroidism.Journal of endocrinological investigation · 2015Article
- Quality of life and health care consumption in primary care patients with elevated serum calcium concentrations in - a prospective, case control, study.BMC family practice · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo follow up patients with elevated calcium concentrations after 10 years.
designLongitudinal, using medical records, questionnaires, and clinical investigation.
settingPrimary care in Tibro, Sweden, 2008-2010. SUBJECTS: 127 patents with elevated calcium concentrations and 254 patients with normal calcium concentrations from the local community, attending the health care centre.
main outcome measuresDiagnoses and mortality in patients with elevated calcium concentrations in 1995-2000, compared with patients with normal calcium concentrations and the background population.
resultsThe proportion of patients for whom no underlying cause was detected decreased from 55% at baseline to 12% at follow-up. Primary hyperparathyroidism was most common in women, 23% at baseline and 36% at follow-up, and the cancer prevalence increased from 5% to 12% in patients with elevated calcium concentration. Mortality tended to be higher in men with elevated calcium concentrations compared with men with normal calcium concentrations, and was significantly higher than in the background population (SMR 2.3, 95% CI 1.3-3.8). Cancer mortality was significantly increased in men (p = 0.039). Low calcium concentrations were also associated with higher mortality (p = 0.004), compared with patients with normal calcium concentrations.
conclusionThis study underscores the importance of investigating patients with increased calcium concentrations suggesting that most of these patients--88% in our study--will turn out to have an underlying disease associated with hypercalcaemia during a 10-year follow-up period. Elevated calcium concentrations had a different disease pattern in men and women, with men showing increased cancer mortality in this study.
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