ArticleMolecular plant pathology2014
FgFim, a key protein regulating resistance to the fungicide JS399-19, asexual and sexual development, stress responses and virulence in Fusarium graminearum.
Article in Molecular plant pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 69 citations in OpenAlex.
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- Crucial Involvement of Heme Biosynthesis in Vegetative Growth, Development, Stress Response, and Fungicide Sensitivity ofInternational journal of molecular sciences · 2024Article
- The ATP Synthase SubunitsInternational journal of molecular sciences · 2023Article
- Strategies for Controlling the Sporulation inJournal of fungi (Basel, Switzerland) · 2022Review
- FaSmi1 Is Essential for the Vegetative Development, Asexual Reproduction, DON Production and Virulence ofJournal of fungi (Basel, Switzerland) · 2022Article
- Retromer subunit, CfVps35 is required for growth development and pathogenicity of Colletotrichum fructicola.BMC genomic data · 2022Article
- FfCOX17 is Involved in Fumonisins Production, Growth, Asexual Reproduction, and Fungicide Sensitivity inToxins · 2022Article
- The plasma membrane HMolecular plant pathology · 2022Article
- S-adenosyl-L-homocysteine hydrolase FgSah1 is required for fungal development and virulence inVirulence · 2021Article
- Functional Roles of αApplied and environmental microbiology · 2021Article
- Deciphering the Dynamics of Signaling Cascades and Virulence Factors ofMicroorganisms · 2021Article
- The ASK1 gene regulates the sensitivity of Fusarium graminearum to carbendazim, conidiation and sexual production by combining with βCurrent genetics · 2021Article
- Structural basis of Fusarium myosin I inhibition by phenamacril.PLoS pathogens · 2020Article
- Characterization ofFrontiers in microbiology · 2020Article
- The Dis1/Stu2/XMAP215 Family GeneFrontiers in microbiology · 2020Article
- Allyl Isothiocyanate (AITC) Triggered Toxicity andFrontiers in microbiology · 2020Article
- Intron-mediated regulation of β-tubulin genes expression affects the sensitivity to carbendazim in Fusarium graminearum.Current genetics · 2019Article
- Involvement of the two L-lactate dehydrogenase in development and pathogenicity in Fusarium graminearum.Current genetics · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fimbrin is an actin-bundling protein found in intestinal microvilli, hair cell stereocilia and fibroblast filopodia. Its homologue Sac6p has been shown to play a critical role in endocytosis and diverse cellular processes in Saccharomyces cerevisiae. FgFim from the wheat scab pathogenic fungus Fusarium graminearum strain Y2021A, which is highly resistant to the fungicide JS399-19, was identified by screening a mutant library generated by HPH-HSV-tk cassette-mediated integration. The functions of FgFim were evaluated by constructing a deletion mutant of FgFim, designated ΔFgFim-15. The deletion mutant exhibited a reduced rate of mycelial growth, reduced conidiation, delayed conidium germination, irregularly shaped hyphae, a lack of sexual reproduction on autoclaved wheat kernels and a dramatic decrease in resistance to JS399-19. ΔFgFim-15 also exhibited increased sensitivity to diverse metal cations, to agents that induce osmotic stress and oxidative stress, and to agents that damage the cell membrane and cell wall. Pathogenicity assays showed that the virulence of the FgFim deletion mutant on flowering wheat heads was impaired, which was consistent with its reduced production of the toxin deoxynivalenol in host tissue. All of these defects were restored by genetic complementation of the mutant with the parental FgFim gene. Quantitative real-time polymerase chain reaction (PCR) assays showed that the basal expression of three Cyp51 genes, which encode sterol 14α-demethylase, was significantly lower in the mutant than in the parental strain. The results of this study indicate that FgFim plays a critical role in the regulation of resistance to JS399-19 and in various cellular processes in F. graminearum.
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