ArticleJournal of clinical and diagnostic research : JCDR2013
Nimesulide induced histopathological changes in the vas deferens of mice.
Article in Journal of clinical and diagnostic research : JCDR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors at 1 institution in 1 country.
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Abstract
aimNimesulide, a preferential COX-2 inhibitor has 20 times more selectivity towards COX-2 than that of COX-1. COX-2 selective inhibitors cause frequent nephrotoxicity and hepatotoxicity following their usage. This proposes a physiological role of COX-2 in kidney and liver. Not much attention has been focused on the role of COX-2 with respect to reproduction especially in male reproduction, and the available information is scanty. AIMs and Objectives: The present study aims to investigate the adverse effects of nimesulide in the vas deferens thereby indirectly assess the role of COX-2 in male reproductive tract. MATERIAL AND
methodsNimesulide was administered orally and the animals were maintained for different time periods prior to sacrifice.
resultsThe vas deferens of nimesulide treated mice showed extensive histopathological changes such as vacoulation and exfoliation of cells in the epithelial layer.
conclusionNimesulide administration leads to cytotoxic effects suggestive of apoptosis in the vas deferens of mice.
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