ArticleNeuroImage. Clinical2014
Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults.
Article in NeuroImage. Clinical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Evaluation of Risk of Bias in Neuroimaging-Based Artificial Intelligence Models for Psychiatric Diagnosis: A Systematic Review.JAMA network open · 2023Pooled it
- Executive Function in High-Functioning Autism Spectrum Disorder: A Meta-analysis of fMRI Studies.Journal of autism and developmental disorders · 2020Pooled it
- Trial
- Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Cognitive Aging Patterns in Autism: Parallel, Accelerated, or Safeguarded?Journal of autism and developmental disorders · 2026Article
- Response Inhibition in Autistic Adults: A Functional Near-Infrared Spectroscopy Study in Virtual Reality.Brain and behavior · 2026Article
- ADHD in Adulthood: Clinical Presentation, Comorbidities, and Treatment Perspectives.International journal of molecular sciences · 2025Review
- Improving interference control without conflict exposure: prefrontal fNIRS-decoded neurofeedback training.Neurophotonics · 2025Article
- Frontal and Parietal Activities Associated With Different Inhibitory Processes in a Stroop-Matching/Stop-Signal Task: A Channel-Wise fNIRS Study.Psychophysiology · 2025Article
- Characterizing Inhibitory Control Challenges Among Autistic Adults: An Examination of Demographic and Psychiatric Moderators and Associations with Anxiety Symptomatology.Journal of autism and developmental disorders · 2025Article
- The Potential of Near-Infrared Spectroscopy as a Therapeutic Tool Following a Stroke (Review).Sovremennye tekhnologii v meditsine · 2025Review
- Applications of Functional Near-Infrared Spectroscopy (fNIRS) Neuroimaging During Rehabilitation Following Stroke: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Sampling inequalities affect generalization of neuroimaging-based diagnostic classifiers in psychiatry.BMC medicine · 2023Article
- Irritability Moderates the Association between Cognitive Flexibility Task Performance and Related Prefrontal Cortex Activation in Young Children.Brain sciences · 2023Article
- Toward Precision Medicine in ADHD.Frontiers in behavioral neuroscience · 2022Review
- Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition.Biology of sex differences · 2021Article
- Application of Near-Infrared Spectroscopy for Evidence-Based Psychotherapy.Frontiers in psychology · 2021Article
- Investigating sensory response to physical discomfort in children with autism spectrum disorder using near-infrared spectroscopy.PloS one · 2021Article
- Synaptosomal-Associated Protein 25 Gene Polymorphisms Affect Treatment Efficiency of Methylphenidate in Children With Attention-Deficit Hyperactivity Disorder: An fNIRS Study.Frontiers in behavioral neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differential diagnosis of autism spectrum disorders (ASDs) and attention deficit hyperactivity disorder (ADHD) based solely on symptomatic and behavioral assessments can be difficult, even for experts. Thus, the development of a neuroimaging marker that differentiates ASDs from ADHD would be an important contribution to this field. We assessed the differences in prefrontal activation between adults with ASDs and ADHD using an entirely non-invasive and portable neuroimaging tool, near-infrared spectroscopy. This study included 21 drug-naïve adults with ASDs, 19 drug-naïve adults with ADHD, and 21 healthy subjects matched for age, sex, and IQ. Oxygenated hemoglobin concentration changes in the prefrontal cortex were assessed during a stop signal task and a verbal fluency task. During the stop signal task, compared to the control group, the ASDs group exhibited lower activation in a broad prefrontal area, whereas the ADHD group showed underactivation of the right premotor area, right presupplementary motor area, and bilateral dorsolateral prefrontal cortices. Significant differences were observed in the left ventrolateral prefrontal cortex between the ASDs and ADHD groups during the stop signal task. The leave-one-out cross-validation method using mean oxygenated hemoglobin changes yielded a classification accuracy of 81.4% during inhibitory control. These results were task specific, as the brain activation pattern observed during the verbal fluency task did not differentiate the ASDs and ADHD groups significantly. This study therefore provides evidence of a difference in left ventrolateral prefrontal activation during inhibitory control between adults with ASDs and ADHD. Thus, near-infrared spectroscopy may be useful as an auxiliary tool for the differential diagnosis of such developmental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.