ArticleBiomedical optics express2013
Photoacoustic microscopy: a potential new tool for evaluation of angiogenesis inhibitor.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- The Chicken Embryo Chorioallantoic Membrane as an In Vivo Model for Photodynamic Therapy.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Photoacoustic imaging of cells in a three-dimensional microenvironment.Journal of biomedical science · 2020Review
- A handheld microscope integrating photoacoustic microscopy and optical coherence tomography.Biomedical optics express · 2018Article
- In vivo deconvolution acoustic-resolution photoacoustic microscopy in three dimensions.Biomedical optics express · 2016Article
- Photoacoustic Tomography Detects Early Vessel Regression and Normalization During Ovarian Tumor Response to the Antiangiogenic Therapy Trebananib.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2015Article
- Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages.Biomedical optics express · 2014Article
- In-Vivo functional optical-resolution photoacoustic microscopy with stimulated Raman scattering fiber-laser source.Biomedical optics express · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The feasibility of photoacoustic microscopy (PAM) for evaluation of angiogenesis inhibitor was investigated on a chick embryo model in vivo. Different concentrations of the angiogenesis inhibitor, Sunitinib, were applied to the chorioallantoic membrane (CAM) of the chick embryos. Imaging of microvasculature in embryo CAMs was acquired using a laser-scanning PAM system; while the optical microscopy (OM) capturing the microvascular images of the same set of CAMs for comparison served as a gold standard for validating the results from PAM. The microvascular density as a function of applied Sunitinib concentration has been quantified in both PAM and OM images. The results from these two modalities have a good agreement, suggesting that PAM could provide an unbiased quantification of microvascular density for objective evaluation of anti-angiogenesis medication. In comparison with conventional OM which enables only two-dimensional enface imaging, PAM is capable of three-dimensional analysis of microvessels, including not only morphology but also functions, as demonstrated in part by the imaging result on a canine bladder model. The emerging PAM technique shows promise to be used in clinical and preclinical settings for comprehensive and objective evaluation of anti-angiogenesis medications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.