ArticleBiomedical optics express2013
High-speed hyperspectral Raman imaging for label-free compositional microanalysis.
Article in Biomedical optics express, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Microplastic Identification Methods for Microfluidic Applications: Towards Rapid Detection in Aquatic Environments.Polymers · 2026Review
- A decade of alkyne-tag Raman imaging (ATRI): applications in biological systems.RSC chemical biology · 2021Review
- Microscopic investigation of" topically applied nanoparticles for molecular imaging of fresh tissue surfaces.Journal of biophotonics · 2018Article
- Tissue diagnosis using power-sharing multifocal Raman micro-spectroscopy and auto-fluorescence imaging.Biomedical optics express · 2016Article
- Noninvasive glucose sensing by transcutaneous Raman spectroscopy.Journal of biomedical optics · 2015Article
- Reagent- and separation-free measurements of urine creatinine concentration using stamping surface enhanced Raman scattering (S-SERS).Biomedical optics express · 2015Article
- Advances in optics for biotechnology, medicine and surgery.Biomedical optics express · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
We present high-speed hyperspectral Raman imaging with integrated active-illumination for label-free compositional microanalysis. We show that high-quality Raman spectra can be acquired from as many as ~1,000 spots/sec semi-randomly distributed among a ~100x100 μm(2) area without mechanical scanning. We demonstrate rapid data acquisition from three types of samples: 1) uniform, strong Raman scatterers, e.g., silicon substrates; 2) non-uniform, medium-strength Raman scatterers, e.g., polymer microparticles; and, 3) non-uniform, relatively weak Raman scatterers, e.g., bacterial spores. We compare the system performance to that of point-scan with an electron-multiplied CCD camera, as implemented in some commercial systems. The results suggest that our system not only provides significant imaging speed advantage for various types of samples, but also permits substantially longer integration time per spot, leading to superior signal-to-noise ratio data. Our system enables the rapid collection of high quality Raman spectra for reliable and robust compositional microanalysis that are potentially transformative in applications such as semiconductor material and device, polymer blend and biomedicine.
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