ArticleInternational journal of stem cells2011
Stem cell therapy in patients with thromboangiitis obliterans: assessment of the long-term clinical outcome and analysis of the prognostic factors.
Article in International journal of stem cells, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Top 100 cited articles in the thromboangiitis obliterans: a bibliometric analysis and visualized study.European journal of medical research · 2023Article
- Cellular therapies in no-option critical limb ischemia: present status and future directions.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2022Review
- Long-term follow-up of patients with Buerger's disease after autologous stem cell therapy.Anatolian journal of cardiology · 2019Article
- Unexpected Inflammation in the Sympathetic Ganglia in Thromboangiitis Obliterans.The International journal of angiology : official publication of the International College of Angiology, Inc · 2017Article
- [Necrosis with mummification of the foot in a 33-year-old man with anxiety disorder].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2017Article
- Therapeutic strategies for cell-based neovascularization in critical limb ischemia.Journal of translational medicine · 2017Review
- Early Results of Clinical Application of Autologous Whole Bone Marrow Stem Cell Transplantation for Critical Limb Ischemia with Buerger's Disease.Scientific reports · 2016Article
- Buerger's disease: providing integrated care.Journal of multidisciplinary healthcare · 2016Review
- Therapeutic Effects of Umbilical Cord Blood Derived Mesenchymal Stem Cell-Conditioned Medium on Pulmonary Arterial Hypertension in Rats.Journal of pathology and translational medicine · 2015Article
- A phase I study of human cord blood-derived mesenchymal stem cell therapy in patients with peripheral arterial occlusive disease.International journal of stem cells · 2013Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe clinical benefits of stem cell therapy have been reported in patients with peripheral arterial occlusive disease. However, those studies had no standard reporting system to assess the outcomes, so we made a scoring system and assessed the outcomes of the limbs that underwent whole bone marrow stem cell (WBMSC) therapy. METHODS AND
resultsBetween July 4 and June 2009, 90 limbs of 67 patients with symptomatic thromboangiitis obliterans (TAO) were enrolled. Autologous whole bone marrow was implanted into the limb by intramuscular injections. The primary outcomes were defined by the clinical and angiographic improvement in all the limbs and the secondary outcomes were the clinical improvement and the amputation-free rates in the critical ischemic limbs (CILs). Clinical improvement and angiographic improvement was observed in 55.6% and 43.2% of all the limbs and in 50% and 50%of the CILs, respectively. The 1, 3 and 5-year amputation-free rates were 91.9%, 88.5% and 84.6% for all the limbs, respectively, and 83.9%, 77.5% and 70.4% for the CILs, respectively. A history of sympathectomy/sympathetic block was shown to be a negative prognostic factor for clinical improvement in all the limbs and in the CILs. In addition, a history of sympathetic block/sympathectomy and the smoking state were the major predictors of amputation for the CILs.
conclusionsThis study indicated that autologous WMBSC therapy improves the clinical status and reduces amputation factors in the limbs with symptomatic TAO and a history of sympathetic block/sympathectomy and the smoking state are useful prognostic factors.
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