ArticleSchizophrenia bulletin2014
Impaired rich club connectivity in unaffected siblings of schizophrenia patients.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
100 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disordersJournal of psychiatry & neuroscience : JPN · 2018Pooled it
- Aberrant Functional Whole-Brain Network Architecture in Patients With Schizophrenia: A Meta-analysis.Schizophrenia bulletin · 2016Pooled it
- Benchmarking overlapping community detection methods for applications in human connectomics.Network neuroscience (Cambridge, Mass.) · 2026Article
- Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies.Brain sciences · 2025Review
- Disrupted intersubject variability architecture in structural and functional brain connectomes in major depressive disorder.Psychological medicine · 2025Article
- Common neuroanatomical differential factors underlying heterogeneous gray matter volume variations in five common psychiatric disorders.Communications biology · 2025Article
- Individualized resting-state functional connectivity abnormalities unveil two major depressive disorder subtypes with contrasting abnormal patterns of abnormality.Translational psychiatry · 2025Article
- Brain rewiring during development: A comparative analysis of larval and adultNetwork neuroscience (Cambridge, Mass.) · 2025Article
- Abnormalities in rich-club connections are associated with an exacerbation of genetic susceptibility to schizophrenia.BMC psychiatry · 2024Article
- Age Trajectories of the Structural Connectome in Child and Adolescent Offspring of Individuals With Bipolar Disorder or Schizophrenia.Biological psychiatry global open science · 2024Article
- Functional and structural reorganization in brain tumors: a machine learning approach using desynchronized functional oscillations.Communications biology · 2024Article
- The characteristic patterns of individual brain susceptibility networks underlie Alzheimer's disease and white matter hyperintensity-related cognitive impairment.Translational psychiatry · 2024Article
- The significance of structural rich club hubs for the processing of hierarchical stimuli.Human brain mapping · 2024Article
- Neurogenetics of Brain Connectivity: Current Approaches to the Study (Review).Sovremennye tekhnologii v meditsine · 2024Review
- Enhanced rich club connectivity in mild or moderate depression after nonpharmacological treatment: A preliminary study.Brain and behavior · 2023Article
- Network biomarkers in recovered psychosis patients who discontinued antipsychotics.Molecular psychiatry · 2023Article
- Altered structural connectome of children with auditory processing disorder: a diffusion MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Rich-club connectivity and structural connectome organization in youth at clinical high-risk for psychosis and individuals with early illness schizophrenia.Schizophrenia research · 2023Article
- Abnormal Structural Network Communication Reflects Cognitive Deficits in Schizophrenia.Brain topography · 2023Article
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia has been conceptualized as a disorder of brain connectivity. Recent studies suggest that brain connectivity may be disproportionally impaired among the so-called rich club. This small core of densely interconnected hub regions has been hypothesized to form an important infrastructure for global brain communication and integration of information across different systems of the brain. Given the heritable nature of the illness, we hypothesized that connectivity disturbances, including abnormal rich club connectivity, may be related to familial vulnerability for schizophrenia. To test this hypothesis, both schizophrenia patients and unaffected siblings of patients were investigated. Rich club organization was examined in networks derived from diffusion-weighted imaging in 40 schizophrenia patients, 54 unaffected siblings of patients, and 51 healthy control subjects. Connectivity between rich club hubs was differentially reduced across groups (P = .014), such that it was highest in controls, intermediate in siblings (7.9% reduced relative to controls), and lowest in patients (19.6% reduced compared to controls). Furthermore, in patients, lower levels of rich club connectivity were found to be related to longer duration of illness and worse overall functioning. Together, these findings suggest that impaired rich club connectivity is related to familial, possibly reflecting genetic, vulnerability for schizophrenia. Our findings support a central role for abnormal rich club organization in the etiology of schizophrenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.