ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Mechanisms of heterosynaptic metaplasticity.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 99 citations in OpenAlex.
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- Churning Better Transcranial Direct Current Stimulation Outcome with Accelerated Protocols: Understanding the Non-linear Dynamics through Metaplasticity.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Review
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- Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change.Neural plasticity · 2024Review
- Mechanisms of Action of TMS in the Treatment of Depression.Current topics in behavioral neurosciences · 2024Review
- Neural learning rules for generating flexible predictions and computing the successor representation.eLife · 2023Article
- Emerging electrolyte-gated transistors for neuromorphic perception.Science and technology of advanced materials · 2023Review
- Role for Astrocytes in mGluR-Dependent LTD in the Neocortex and Hippocampus.Brain sciences · 2022Article
- Critical considerations of the contribution of the corticomotoneuronal pathway to central fatigue.The Journal of physiology · 2022Review
- Pathway-specific TNF-mediated metaplasticity in hippocampal area CA1.Scientific reports · 2022Article
- Foxa1 mediates eccrine sweat gland development through transcriptional regulation of Na-K-ATPase expression.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- On-device synaptic memory consolidation using Fowler-Nordheim quantum-tunneling.Frontiers in neuroscience · 2022Article
- Time-dependent changes in hippocampal and striatal glycogen long after maze training in male rats.Neurobiology of learning and memory · 2021Article
- Daily acute intermittent hypoxia enhances phrenic motor output and stimulus-evoked phrenic responses in rats.Journal of neurophysiology · 2021Article
- Remote muscle priming anodal transcranial direct current stimulation attenuates short interval intracortical inhibition and increases time to task failure of a constant workload cycling exercise.Experimental brain research · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic plasticity is fundamental to the neural processes underlying learning and memory. Interestingly, synaptic plasticity itself can be dynamically regulated by prior activity, in a process termed 'metaplasticity', which can be expressed both homosynaptically and heterosynaptically. Here, we focus on heterosynaptic metaplasticity, particularly long-range interactions between synapses spread across dendritic compartments, and review evidence for intracellular versus intercellular signalling pathways leading to this effect. Of particular interest is our previously reported finding that priming stimulation in stratum oriens of area CA1 in the hippocampal slice heterosynaptically inhibits subsequent long-term potentiation and facilitates long-term depression in stratum radiatum. As we have excluded the most likely intracellular signalling pathways that might mediate this long-range heterosynaptic effect, we consider the hypothesis that intercellular communication may be critically involved. This hypothesis is supported by the finding that extracellular ATP hydrolysis, and activation of adenosine A2 receptors are required to induce the metaplastic state. Moreover, delivery of the priming stimulation in stratum oriens elicited astrocytic calcium responses in stratum radiatum. Both the astrocytic responses and the metaplasticity were blocked by gap junction inhibitors. Taken together, these findings support a novel intercellular communication system, possibly involving astrocytes, being required for this type of heterosynaptic metaplasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.