ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Long-term potentiation in the anterior cingulate cortex and chronic pain.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
112 citing papers in PubMed, 191 citations in OpenAlex.
- Transcranial Direct Current Stimulation for Affective Symptoms and Functioning in Chronic Low Back Pain: A Pilot Double-Blinded, Randomized, Placebo-Controlled Trial.Pain medicine (Malden, Mass.) · 2019Trial
- The effects of inpatient versus outpatient spa therapy on pain, anxiety, and quality of life in elderly patients with generalized osteoarthritis: a pilot study.International journal of biometeorology · 2018Trial
- Transcranial Direct Current Stimulation (tDCS) Targeting Left Dorsolateral Prefrontal Cortex Modulates Task-Induced Acute Pain in Healthy Volunteers.Pain medicine (Malden, Mass.) · 2016Trial
- Mental imagery-induced attention modulates pain perception and cortical excitability.BMC neuroscience · 2015Trial
- Distinct parafascicular neuronal ensembles mediate the sensory and affective dimensions of trigeminal neuralgia.The Journal of clinical investigation · 2026Article
- Lysophosphatidic acid drives to mirror-image pain via corpus callosum-mediated propagation of inflammatory responses.Communications biology · 2026Article
- Caudal Granular Insular Cortex to Somatosensory Cortex I: A Critical Pathway for the Transition of Acute to Chronic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Pain-Related Social and Behavioral Changes: a Complex Interplay.Current pain and headache reports · 2026Review
- Synaptic plasticity in affective comorbidities of neuropathic pain: a bibliometric analysis based on WoSCC and PubMed (2003-2025).Frontiers in neurology · 2026Article
- Impact of adolescent ethanol binge on serotonin signaling and pain sensitivity post-withdrawal.Alcohol (Fayetteville, N.Y.) · 2025Article
- Tuina Alleviates Anxiety-Like Behaviors Associated With Neuropathic Pain Through the Modulation of Synaptic Plasticity in the Anterior Cingulate Cortex.Brain and behavior · 2025Article
- IRF1 ameliorates synaptic dysfunction through the modulation of O-GlcNAcylation on GluN1 subunit of NMDAR.Alzheimer's research & therapy · 2025Article
- Voluntary running improves synaptic degeneration of the anterior cingulate cortex in knee osteoarthritis.Molecular brain · 2025Article
- The relationship between abnormal glucose metabolism and chronic pain.Cell & bioscience · 2025Review
- Targeting PI3K-mTOR signaling in the anterior cingulate cortex improves emotional behavior, and locomotor activity in rats with bone cancer pain.Annals of medicine and surgery (2012) · 2025Article
- mGluR5-mediated astrocytes hyperactivity in the anterior cingulate cortex contributes to neuropathic pain in male mice.Communications biology · 2025Article
- IDO1 modulates pain sensitivity and comorbid anxiety in chronic migraine through microglial activation and synaptic pruning.Journal of neuroinflammation · 2025Article
- Integrating Telemedicine and Embodied Virtual Reality: A Novel Functional Training Intervention for Chronic Shoulder Pain.Journal of medical extended reality · 2025Article
- Experiencing pain: electromagnetic waves, consciousness, and the mind.Frontiers in human neuroscience · 2025Article
- Zingerone alleviates inflammatory pain by reducing the intrinsic excitability of anterior cingulate cortex neurons in a mice model.Frontiers in pharmacology · 2025Article
52 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glutamate is the primary excitatory transmitter of sensory transmission and perception in the central nervous system. Painful or noxious stimuli from the periphery 'teach' humans and animals to avoid potentially dangerous objects or environments, whereas tissue injury itself causes unnecessary chronic pain that can even last for long periods of time. Conventional pain medicines often fail to control chronic pain. Recent neurobiological studies suggest that synaptic plasticity taking place in sensory pathways, from spinal dorsal horn to cortical areas, contributes to chronic pain. Injuries trigger long-term potentiation of synaptic transmission in the spinal cord dorsal horn and anterior cingulate cortex, and such persistent potentiation does not require continuous neuronal activity from the periphery. At the synaptic level, potentiation of excitatory transmission caused by injuries may be mediated by the enhancement of glutamate release from presynaptic terminals and potentiated postsynaptic responses of AMPA receptors. Preventing, 'erasing' or reducing such potentiation may serve as a new mechanism to inhibit chronic pain in patients in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.