ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Spike-timing-dependent BDNF secretion and synaptic plasticity.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Solubilized β-Glucan Supplementation in C57BL/6J Mice Dams Augments Neurodevelopment and Cognition in the Offspring Driven by Gut Microbiome Remodeling.Foods (Basel, Switzerland) · 2024Article
- Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity.eLife · 2022Article
- Cell-type-specific neuromodulation guides synaptic credit assignment in a spiking neural network.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses.Cells · 2021Review
- A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity.Molecular brain · 2021Article
- Cognitive Development and Brain Gray Matter Susceptibility to Prenatal Adversities: Moderation by the Prefrontal Cortex Brain-Derived Neurotrophic Factor Gene Co-expression Network.Frontiers in neuroscience · 2021Article
- The physiology of regulated BDNF release.Cell and tissue research · 2020Review
- Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Post-stroke remodeling processes in animal models and humans.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Review
- Long-term population spike-timing-dependent plasticity promotes synaptic tagging but not cross-tagging in rat hippocampal area CA1.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Decreased BDNF Release in Cortical Neurons of a Knock-in Mouse Model of Huntington's Disease.Scientific reports · 2018Article
- Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Enhances Hippocampal Synaptic Plasticity and Improves Memory Performance in Huntington's Disease.Molecular neurobiology · 2018Article
- Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses.Cell reports · 2018Article
- Cortical Axonal Secretion of BDNF in the Striatum Is Disrupted in the Mutant-huntingtin Knock-in Mouse Model of Huntington's Disease.Experimental neurobiology · 2018Article
- Modulation of Spike-Timing Dependent Plasticity: Towards the Inclusion of a Third Factor in Computational Models.Frontiers in computational neuroscience · 2018Review
- Neuronal activity-dependent local activation of dendritic unfolded protein response promotes expression of brain-derived neurotrophic factor in cell soma.Journal of neurochemistry · 2018Article
- Coexistence of Multiple Types of Synaptic Plasticity in Individual Hippocampal CA1 Pyramidal Neurons.Frontiers in synaptic neuroscience · 2017Article
- Neuronal Gene Targets of NF-κB and Their Dysregulation in Alzheimer's Disease.Frontiers in molecular neuroscience · 2016Review
- Activity-dependent BDNF release via endocytic pathways is regulated by synaptotagmin-6 and complexin.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Gabapentin prevents oxaliplatin-induced central sensitization in the dorsal horn neurons in rats.Iranian journal of basic medical sciences · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In acute hippocampal slices, we found that the presence of extracellular brain-derived neurotrophic factor (BDNF) is essential for the induction of spike-timing-dependent long-term potentiation (tLTP). To determine whether BDNF could be secreted from postsynaptic dendrites in a spike-timing-dependent manner, we used a reduced system of dissociated hippocampal neurons in culture. Repetitive pairing of iontophoretically applied glutamate pulses at the dendrite with neuronal spikes could induce persistent alterations of glutamate-induced responses at the same dendritic site in a manner that mimics spike-timing-dependent plasticity (STDP)-the glutamate-induced responses were potentiated and depressed when the glutamate pulses were applied 20 ms before and after neuronal spiking, respectively. By monitoring changes in the green fluorescent protein (GFP) fluorescence at the dendrite of hippocampal neurons expressing GFP-tagged BDNF, we found that pairing of iontophoretic glutamate pulses with neuronal spiking resulted in BDNF secretion from the dendrite at the iontophoretic site only when the glutamate pulses were applied within a time window of approximately 40 ms prior to neuronal spiking, consistent with the timing requirement of synaptic potentiation via STDP. Thus, BDNF is required for tLTP and BDNF secretion could be triggered in a spike-timing-dependent manner from the postsynaptic dendrite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.