Evidence map›Paper›PMID 24297872›Full record

SynthesisBlood2014

A systematic analysis of global anemia burden from 1990 to 2010.

Nicholas J Kassebaum, Rashmi Jasrasaria, Mohsen Naghavi, Sarah K Wulf, Nicole Johns, Rafael Lozano, Mathilda Regan, David Weatherall, David P Chou, Thomas P Eisele and 4 more

5 registry-linked trialsAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 952 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
952citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03866837 nacompletednot on this mapstarted 2020, after this paper: background citation

Prebiotic GOS and Lactoferrin for Beneficial Gut Microbiota With Iron Supplements

TypeinterventionalSponsorColumbia UniversityRan2020 to 2023Enrolled288ConditionsIron-deficiencyArmsGalacto-oligosaccharides, Bovine lactoferrin, Multiple micronutrient powders with 5 mg iron
NCT05217836 unknown statusnot on this mapstarted 2021, after this paper: background citation

Iron Metabolism Disorders in Patients With Sepsis or Septic Shock. Diagnosis and Monitoring of Treatment Based on Standard and New Laboratory Parameters.

TypeobservationalSponsorMedical University of SilesiaRan2021 to 2022Enrolled90ConditionsIron-deficiency, Iron Deficiency Anemia, Anemia of Chronic Disease, SepsisArmsferritin, iron, transferrin, transferrin saturation, hemoglobin in reticulocyte
NCT05669209 completednot on this mapstarted 2022, after this paper: background citation

Etiology and Contributing Factors of Anemia Among Women of Reproductive Age at Kebribeyah District in the Somali Regional State, Ethiopia

TypeobservationalSponsorEthiopian Public Health InstituteRan2022 to 2023Enrolled881ConditionsAnemia
NCT07083583 recruitingnot on this mapstarted 2025, after this paper: background citation

Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders: a Single-arm Prospective Observational Study

TypeobservationalSponsorNicoletta C MachinRan2025 to 2027Enrolled40ConditionsBleeding Disorders, Iron, Platelet, BleedingArmsIV Iron (standard of care)
NCT07661602 phase3not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Gut Microbiota-Mediated Effects of Precision Dietary Interventions on Anemia Among Nepalese Adolescents

TypeinterventionalSponsorSouthern Medical University, ChinaRan2026 to 2026Enrolled60ConditionsAnemiaArmsIron folic acid supplement, Goat liver supplementation, Nutrition education on anemia prevention and control
3 · Its place in the literature

Who cites it

952 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Guideline
  8. Pooled it
  9. Trial
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  16. Review
  17. Mechanisms of Thrombocytosis in Iron-Deficiency Anemia.European journal of haematology · 2026
    Review
  18. Article
  19. Article
  20. The N6-methyladenosine (mBritish journal of haematology · 2026
    Article

892 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Nicholas J KassebaumInstitute for Health Metrics and Evaluation, University of Washington, Seattle, WA;
Rashmi Jasrasaria
Mohsen Naghavi
Sarah K Wulf
Nicole Johns
Rafael Lozano
Mathilda Regan
David Weatherall
David P Chou
Thomas P Eisele
Seth R Flaxman
Rachel L Pullan
Simon J Brooker
Christopher J L Murray

Funding

Medical Research Council MC_UU_12009/13Wellcome Trust 092654Wellcome Trust 098045
6 · The paper itself

Abstract

Previous studies of anemia epidemiology have been geographically limited with little detail about severity or etiology. Using publicly available data, we estimated mild, moderate, and severe anemia from 1990 to 2010 for 187 countries, both sexes, and 20 age groups. We then performed cause-specific attribution to 17 conditions using data from the Global Burden of Diseases, Injuries and Risk Factors (GBD) 2010 Study. Global anemia prevalence in 2010 was 32.9%, causing 68.36 (95% uncertainty interval [UI], 40.98 to 107.54) million years lived with disability (8.8% of total for all conditions [95% UI, 6.3% to 11.7%]). Prevalence dropped for both sexes from 1990 to 2010, although more for males. Prevalence in females was higher in most regions and age groups. South Asia and Central, West, and East sub-Saharan Africa had the highest burden, while East, Southeast, and South Asia saw the greatest reductions. Iron-deficiency anemia was the top cause globally, although 10 different conditions were among the top 3 in regional rankings. Malaria, schistosomiasis, and chronic kidney disease-related anemia were the only conditions to increase in prevalence. Hemoglobinopathies made significant contributions in most populations. Burden was highest in children under age 5, the only age groups with negative trends from 1990 to 2010.

Indexed as

Global HealthAge FactorsAnemiaFemaleGeography, MedicalHumansMalePrevalenceRisk FactorsSex Factors

Identifiers

PMID24297872
PMCPMC3907750

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.