ArticleThe Journal of physiology2014
Synaptic noise is an information bottleneck in the inner retina during dynamic visual stimulation.
Article in The Journal of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A heterogeneous population code at the first synapse of vision.Nature communications · 2026Article
- Quantifying the link between retinal performance and the optomotor response.Current biology : CB · 2025Article
- Substance P and dopamine form a "push-pull" system that diurnally regulates retinal gain.Current biology : CB · 2024Article
- The Interplay between Neurotransmitters and Calcium Dynamics in Retinal Synapses during Development, Health, and Disease.International journal of molecular sciences · 2024Review
- Diurnal changes in the efficiency of information transmission at a sensory synapse.Nature communications · 2022Article
- Glycine Release Is Potentiated by cAMP via EPAC2 and CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Efficient population coding depends on stimulus convergence and source of noise.PLoS computational biology · 2021Article
- Asymmetry between ON and OFF α ganglion cells of mouse retina: integration of signal and noise from synaptic inputs.The Journal of physiology · 2017Article
- A Mammalian Retinal Ganglion Cell Implements a Neuronal Computation That Maximizes the SNR of Its Postsynaptic Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- How Do Efficient Coding Strategies Depend on Origins of Noise in Neural Circuits?PLoS computational biology · 2016Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In daylight, noise generated by cones determines the fidelity with which visual signals are initially encoded. Subsequent stages of visual processing require synapses from bipolar cells to ganglion cells, but whether these synapses generate a significant amount of noise was unknown. To characterize noise generated by these synapses, we recorded excitatory postsynaptic currents from mammalian retinal ganglion cells and subjected them to a computational noise analysis. The release of transmitter quanta at bipolar cell synapses contributed substantially to the noise variance found in the ganglion cell, causing a significant loss of fidelity from bipolar cell array to postsynaptic ganglion cell. Virtually all the remaining noise variance originated in the presynaptic circuit. Circuit noise had a frequency content similar to noise shared by ganglion cells but a very different frequency content from noise from bipolar cell synapses, indicating that these synapses constitute a source of independent noise not shared by ganglion cells. These findings contribute a picture of daylight retinal circuits where noise from cones and noise generated by synaptic transmission of cone signals significantly limit visual fidelity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.