ArticleHuman genetics2014
Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants.
Article in Human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder.Nature communications · 2026Article
- Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.Nature communications · 2019Article
- Shared additive genetic variation for alcohol dependence among subjects of African and European ancestry.Addiction biology · 2019Article
- Accounting for heteroscedasticity and censoring in chromosome partitioning analyses.Evolution letters · 2018Article
- Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples.Alcoholism, clinical and experimental research · 2018Article
- Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems.Alcoholism, clinical and experimental research · 2018Article
- Review: DNA methylation and alcohol use disorders: Progress and challenges.The American journal on addictions · 2017Review
- Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.Alcoholism, clinical and experimental research · 2015Review
- Genome-wide association study of copy number variations (CNVs) with opioid dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Examining the role of common genetic variants on alcohol, tobacco, cannabis and illicit drug dependence: genetics of vulnerability to drug dependence.Addiction (Abingdon, England) · 2015Article
- Implications of pleiotropy: challenges and opportunities for mining Big Data in biomedicine.Frontiers in genetics · 2015Review
- GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Alcohol dependence (AD) is a complex psychiatric disorder that affects about 12.5 % of US adults. Genetic factors play a major role in the development of AD. We conducted a genomewide association study in 2,875 African-Americans including 1,719 AD cases and 1,156 controls. We used the Illumina Omni 1-Quad microarray, which yielded 769,498 single-nucleotide polymorphisms (SNPs) after quality control. To explore the genetic architecture of AD, we estimated the variance that could be explained by all SNPs and subsets of SNPs using two different approaches to genome partitioning. We found that 23.9 % (s.e. 9.3 %) of the phenotypic variance could be explained by using all of the common SNPs on the array. We also found a significant linear relationship between the proportion of the top SNPs used and the phenotypic variance explained by them. Based on genome partitioning of common variants, we also observed a significant linear relationship between the variance explained by a chromosome and its length. Chromosome 4, known to contain several AD risk genes, accounted for excess risk in proportion to its length. By functional partitioning, we found that the genetic variants within 20 kb of genes explained 17.5 % (s.e. 11.4 %) of the phenotypic variance. Our findings are consistent with the generally accepted view that AD is a highly polygenic trait, i.e., the genetic risk in AD appears to be conferred by multiple variants, each of which may have a small or moderate effect.
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