ArticleInternational orthopaedics2014
Relationship of plasma and synovial fluid vascular endothelial growth factor with radiographic severity in primary knee osteoarthritis.
Article in International orthopaedics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Pooled it
- Clinically Relevant Molecular Biomarkers for Use in Human Knee Osteoarthritis: A Systematic Review.Cartilage · 2021Pooled it
- Elevated VEGF levels contribute to the pathogenesis of osteoarthritis.BMC musculoskeletal disorders · 2014Pooled it
- Plasma and Synovial Fluid VEGF-A and Neuropilin-1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization-Related Features, and Disease Burden.The Kaohsiung journal of medical sciences · 2026Article
- Spatial lipid-barrier coupling in knee osteoarthritis: a mechanism-based perspective centered on the infrapatellar fat pad.Therapeutic advances in musculoskeletal disease · 2026Review
- Apelin: A Promising Therapeutic Target for Degenerative Diseases of the Musculoskeletal System.Aging and disease · 2025Review
- Serum biomarkers for diagnosis and severity evaluation in knee osteoarthritis.American journal of translational research · 2025Article
- Disease-Modifying Effects of Lenvatinib, a Multiple Receptor Tyrosine Kinase Inhibitor, on Posttraumatic Osteoarthritis of the Knee.International journal of molecular sciences · 2024Article
- Concentration of synovial fluid biomarkers on the day of anterior cruciate ligament (ACL)-reconstruction predict size and depth of cartilage lesions on 5-year follow-up.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Biomarkers of Osteoarthritis-A Narrative Review on Causal Links with Metabolic Syndrome.Life (Basel, Switzerland) · 2023Review
- Sex-specific effects of calving season on joint health and biomarkers in Montana ranchers.BMC musculoskeletal disorders · 2023Article
- Potential Therapeutic Mechanism of Radix Angelicae Biseratae and Dipsaci Radix Herb Pair against Osteoarthritis: Based on Network Pharmacology and Molecular Docking.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Association between Common Variants inCartilage · 2022Article
- Female rats have a different healing phenotype than males after anterior cruciate ligament rupture with no intervention.Frontiers in medicine · 2022Article
- Article
- Article
- Network Pharmacology Approach to Uncover the Mechanism Governing the Effect of Simiao Powder on Knee Osteoarthritis.BioMed research international · 2020Article
- Vascular Endothelial Growth Factor Is Regulated by the Canonical and Noncanonical Transforming Growth Factor-BioMed research international · 2019Article
- Increase in mast cell marker expression in the synovium of obese patients with osteoarthritis of the knee.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Vascular endothelial growth factor expression and their action in the synovial membranes of patients with painful knee osteoarthritis.BMC musculoskeletal disorders · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecent evidence suggests that angiogenesis and inflammation contribute to the development and progression of osteoarthritis (OA). The purpose of this study was to investigate vascular endothelial growth factor (VEGF) levels in plasma and synovial fluid of patients with knee OA and to determine the relationship of VEGF levels with disease severity in knee OA.
methodsA total of 100 subjects were enrolled in this study (80 knee OA patients and 20 healthy controls). Plasma and synovial fluid VEGF levels were analysed using enzyme-linked immunosorbent assay. VEGF expressions in synovial membrane and articular cartilage samples were assessed using immunohistochemistry.
resultsVEGF level in synovial fluid of knee OA patients was tenfold higher than that in paired plasma (P < 0.001). Both plasma and synovial fluid VEGF exhibited a positive correlation with radiographic severity (r = 0.454 and r = 0.727, P < 0.001, respectively). VEGF expression was highly detectable in synovial lining cells and articular chondrocytes of knee OA patients.
conclusionsVEGF levels in both plasma and synovial fluid were positively correlated with the severity of knee OA. Therefore, VEGF may be useful for monitoring OA severity and could play a substantial role in the development and progression of knee OA.
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Registered trials
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