ArticleCell stress & chaperones2014
Characterization of the small heat shock protein Hsp27 gene in Chironomus riparius (Diptera) and its expression profile in response to temperature changes and xenobiotic exposures.
Article in Cell stress & chaperones, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 96 citations in OpenAlex.
- Temperature and spinosad-induced modulation of antioxidant enzyme activity and gene expression of adaptive stress-related genes inOpen veterinary journal · 2025Review
- A Review on the Involvement of Heat Shock Proteins (Extrinsic Chaperones) in Response to Stress Conditions in Aquatic Organisms.Antioxidants (Basel, Switzerland) · 2023Review
- Effects of eicosapentaenoic acid supplementation on heat shock protein 27, glycemic status and anthropometric indices in type 2 diabetes patients.Journal of diabetes and metabolic disorders · 2023Article
- Graphene Oxides (GOs) with Different Lateral Dimensions and Thicknesses Affect the Molecular Response inNanomaterials (Basel, Switzerland) · 2023Article
- Article
- Persistent pesticides: effects of endosulfan at the molecular level on the aquatic invertebrate Chironomus riparius.Environmental science and pollution research international · 2021Article
- Teratological changes in postembryos ofPeerJ · 2021Article
- Molecular cloning and characterization of HSP60 gene in domestic pigeons (Columba livia) and differential expression patterns under temperature stress.Cell stress & chaperones · 2021Article
- Antioxidant Enzymes and Heat-Shock Protein Genes of Green Peach Aphid (Frontiers in physiology · 2021Article
- Skeletal muscle cold shock and heat shock protein mRNA response to aerobic exercise in different environmental temperatures.Temperature (Austin, Tex.) · 2019Article
- Prodiamesa olivacea Meigen and Prodiamesa bureshi Michailova (Diptera, Chironomidae, Prodiamesinae) as a candidate for assessing the genotoxicity of trace metals in fluvial sediments.Environmental monitoring and assessment · 2018Article
- Toxic Effects of Bisphenol A, Propyl Paraben, and Triclosan on Caenorhabditis elegans.International journal of environmental research and public health · 2018Article
- Environmental Stress Responses ofFrontiers in genetics · 2018Article
- Ultraviolet filters and heat shock proteins: effects in Chironomus riparius by benzophenone-3 and 4-methylbenzylidene camphor.Environmental science and pollution research international · 2018Article
- hsp90 and hsp47 appear to play an important role in minnow Puntius sophore for surviving in the hot spring run-off aquatic ecosystem.Fish physiology and biochemistry · 2017Article
- The Potential Coordination of the Heat-Shock Proteins and Antioxidant Enzyme Genes ofFrontiers in physiology · 2017Article
- Identification of multiple small heat-shock protein genes in Plutella xylostella (L.) and their expression profiles in response to abiotic stresses.Cell stress & chaperones · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small heat shock proteins constitute the most diverse and least conserved group within the large family of heat shock proteins, which play a crucial role in cell response to environmental insults. Chironomus riparius larvae are widely used in environmental research for testing pollutant toxicity in sediments and freshwater environments. Different genes, such as Hsp70, Hsc70, Hsp90, and Hsp40, have been identified in this species as sensitive biomarkers for xenobiotics, but small Hsps genes remain largely unknown. In this study, the Hsp27 has been characterized in C. riparius and its transcriptional response evaluated under several environmental stimuli. The Hsp27 gene was mapped by FISH on polytene chromosomes at region I-C4 and was found to encode a 195 aa protein, which contains an α-crystallin domain bounded by three conserved regions. This protein shows homology with Drosophila melanogaster HSP27, Ceratitis capitata HSP27, and Sarcophaga crassipalpis HSP25. Real-time reverse transcriptase-polymerase chain reaction analysis showed that heat shock (35 °C) and cadmium dramatically upregulate this gene. Moreover, exposures to triclosan and bisphenol A were able to significantly increase mRNA levels. However, neither nonylphenol nor tributyltin altered Hsp27 gene expression. The transcriptional activity of Hsp27 gene was modulated during cold stress. Interestingly, cold shock (4 °C) significantly reduced Hsp27 transcripts, but this gene was significantly overexpressed during the recovery time at the normal growing temperature. These results show that the Hsp27 gene is sensitive to different environmental stimuli, including endocrine-disrupting pollutants, suggesting its potential as a suitable biomarker for ecotoxicological studies in aquatic systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.