SynthesisTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2014
Assessment of the association between hOGG1 C8069G polymorphism and colorectal cancer.
Synthesis in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- DNA repair and cancer in colon and rectum: Novel players in genetic susceptibility.International journal of cancer · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human oxoguanine glycosylase 1 (hOGG1) is an important part in the base excision repair (BER) pathway of DNA repair. Numerous epidemiological studies were published to assess the association between hOGG1 C8069G polymorphism and risk of colorectal cancer, but they reported contradictory results. A meta-analysis was performed to clarify the effect of hOGG1 C8069G polymorphism on colorectal cancer. The association was assessed by calculating the pooled odds ratio (OR) with 95% confidence interval (95 %CI). Twenty-one studies with a total of 14,492 participants were finally included into the meta-analysis. Overall, there was an obvious association between hOGG1 C8069G polymorphism and increased risk of colorectal cancer under all four genetic models (G vs. C: OR = 1.17, 95%CI 1.05-1.30, P = 0.003; GG vs. CC: OR = 1.39, 95%CI 1.11-1.74, P = 0.004; GG/CG vs. CC: OR = 1.20, 95%CI 1.04-1.37, P = 0.010; GG vs. CC/CG: OR = 1.23, 95%CI 1.03-1.46, P = 0.020). Subgroup analysis based on ethnicity showed that there was an obvious association between hOGG1 C8069G polymorphism and increased risk of colorectal cancer in the Caucasian population but not in the Asian population. The findings from the meta-analysis suggest that there is an obvious association between hOGG1 C8069G polymorphism and increased risk of colorectal cancer, especially in the Caucasian population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.