ArticleJournal of the Association for Research in Otolaryngology : JARO2014
Input-output functions of vestibular afferent responses to air-conducted clicks in rats.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Utricular Compound Action Potential Thresholds to Pulsed Interaural Vibration in Guinea Pig, and Mechanical Tuning Curve Estimates in Mouse, Rat, Sheep, and Human.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Progression of Vestibular Deficits Following Moderate-Intensity Blast Overpressure in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Assessment of Semicircular Canal Functioning Using a Video Head Impulse Test in Individuals with Occupational Noise Exposure.Journal of the American Academy of Audiology · 2025Article
- Opinion: the neural basis of vestibular evoked myogenic potentials. The cVEMP is a specific indicator of saccular function.Frontiers in neurology · 2025Article
- Skull vibration induced nystagmus, velocity storage and self-stability.Frontiers in neurology · 2025Article
- The neural basis of vestibular evoked myogenic potentials. The cVEMP is a specific indicator of saccular function.Frontiers in neurology · 2025Review
- After the n10: late oVEMP peaks in patients with unilateral vestibular loss and healthy volunteers.Experimental brain research · 2024Article
- Pharmacological regeneration of sensory hair cells restores afferent innervation and vestibular function.The Journal of clinical investigation · 2024Article
- Role of Video Head Impulse Test to Assess Noise Exposure.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Thirty years with cervical vestibular myogenic potentials: a critical review on its origin.Frontiers in neurology · 2024Review
- Vestibulospinal reflexes elicited with a tone burst method are dependent on spatial orientation.PeerJ · 2024Article
- Using macular velocity measurements to relate parameters of bone conduction to vestibular compound action potential responses.Scientific reports · 2023Article
- A reliable and reproducible protocol for sound-evoked vestibular myogenic potentials in rattus norvegicus.Frontiers in integrative neuroscience · 2023Article
- A mathematical model for mechanical activation and compound action potential generation by the utricle in response to sound and vibration.Frontiers in neurology · 2023Article
- Differential Activation of Canal and Otolith Afferents by Acoustic Tone Bursts in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Editorial: Commonalities and Differences in Vestibular and Auditory Pathways.Frontiers in neuroscience · 2022Article
- Sound-Evoked Responses in the Vestibulo-Ocular Reflex Pathways of Rats.Frontiers in neuroscience · 2021Article
- Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- Exposure to blast shock waves via the ear canal induces deficits in vestibular afferent function in rats.Journal of otology · 2020Article
- Intense noise exposure alters peripheral vestibular structures and physiology.Journal of neurophysiology · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Sound-evoked vestibular myogenic potentials recorded from the sternocleidomastoid muscles (the cervical vestibular-evoked myogenic potential or cVEMP) and the extraocular muscles (the ocular VEMP or oVEMP) have proven useful in clinical assessment of vestibular function. VEMPs are commonly interpreted as a test of saccular function, based on neurophysiological evidence showing activation of saccular afferents by intense acoustic click stimuli. However, recent neurophysiological studies suggest that the clicks used in clinical VEMP tests activate vestibular end organs other than the saccule. To provide the neural basis for interpreting clinical VEMP testing results, the present study examined the extent to which air-conducted clicks differentially activate the various vestibular end organs at several intensities and durations in Sprague-Dawley rats. Single unit recordings were made from 562 vestibular afferents that innervated the otoliths [inferior branch otolith (IO) and superior branch otolith (SO)], the anterior canal (AC), the horizontal canal (HC), and the posterior canal (PC). Clicks higher than 60 dB SL (re-auditory brainstem response threshold) activated both semicircular canal and otolith organ afferents. Clicks at or below 60 dB SL, however, activated only otolith organ afferents. Longer duration clicks evoked larger responses in AC, HC, and SO afferents, but not in IO afferents. Intra-axonal recording and labeling confirmed that sound sensitive vestibular afferents innervated the horizontal and anterior canal cristae as well as the saccular and utricular maculae. Interestingly, all sound sensitive afferents are calyx-bearing fibers. These results demonstrate stimulus-dependent acoustic activation of both semicircular canals and otolith organs, and suggest that sound activation of vestibular end organs other than the saccule should not be ruled out when designing and interpreting clinical VEMP tests.
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